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KRTAP10-8 and HCK
Data Source:
BioGRID
(two hybrid)
KRTAP10-8
HCK
Description
keratin associated protein 10-8
HCK proto-oncogene, Src family tyrosine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Keratin Filament
Nucleus
Lysosome
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Transport Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cell Projection
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Biological Process
Keratinization
Leukocyte Migration Involved In Immune Response
Innate Immune Response-activating Signal Transduction
Protein Phosphorylation
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Apoptotic Process
Leukocyte Degranulation
Innate Immune Response
Respiratory Burst After Phagocytosis
Protein Autophosphorylation
Regulation Of Defense Response To Virus By Virus
Regulation Of Inflammatory Response
Regulation Of Phagocytosis
Regulation Of DNA-binding Transcription Factor Activity
Interferon-gamma-mediated Signaling Pathway
Regulation Of Podosome Assembly
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Keratinization
Nef and signal transduction
FCGR activation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Drugs
1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Phosphonotyrosine
Quercetin
Bosutinib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Inflammatory bowel disease (
23128233
)
Migraine (
27322543
)
Interacting Genes
388 interacting genes:
-
ACY3
ADAM12
ADAMTS1
ADAMTSL3
ADAMTSL4
AEBP2
AEN
AK3
ALDH3B1
ALPI
ALPP
AMMECR1
ANKS1A
AP1M1
APOL6
AQP1
AREG
ARID5A
ASPSCR1
ATG9A
ATP5F1D
AVPI1
AXIN2
BAHD1
BCL6B
BEX2
BMP7
BRME1
C10orf62
C11orf87
C17orf50
C19orf25
C22orf39
C2orf68
C3
CAMK1G
CARD10
CARHSP1
CATSPER1
CCDC26
CCNJL
CHIC2
CHRD
CHRNG
CLK4
CNNM3
COL8A1
COX17
CRCT1
CREB5
CRH
CRY2
CSF1
CTRC
CYP2S1
CYSRT1
DAAM2
DCX
DDX43
DDX55
DDX6
DERL2
DHRS1
DHX57
DMRT3
DOCK2
ECE1
EFEMP2
EIF4E2
ENKD1
EPDR1
FADS6
FAH
FAM110A
FAM161A
FAM221B
FAM27E3
FAM71C
FAM74A4
FAM76B
FAM90A1
FARS2
FBXO34
FBXW5
FEZF1
FOXB1
FRS3
FTHL17
FZD10
GEM
GFOD1
GLIDR
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GOLGA8EP
GPANK1
GPHB5
GPRIN2
GRN
GUCD1
HAPLN2
HCK
HHEX
HOXA1
HOXB5
HOXB9
HOXC8
HPCAL1
HS6ST1
HSD3B7
HSPA12B
HSPD1
ICAM1
IGFBP6
IGSF8
IL10
IL16
IL2RG
INO80B
INTS5
IP6K3
ITGB2
ITGB4
ITGB5
JOSD1
JPH3
KLHL38
KLK8
KPRP
KRT20
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP15-1
KRTAP17-1
KRTAP19-7
KRTAP3-1
KRTAP3-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LAGE3
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LELP1
LENG1
LINC00656
LMF2
LNX1
LRCH4
LRFN4
LUZP4
LYVE1
MACROH2A1
MAPKBP1
MATN3
MEIS2
MELTF
MEOX2
MLLT6
MOBP
MTA1
MUL1
MXI1
MYPOP
NAB2
NAXD
NBPF19
NECTIN2
NECTIN3
NEK6
NKD1
NOTCH2NLA
NPDC1
NR1D2
NR4A3
NTN4
NUFIP2
OLIG3
OPCML
OTX1
P2RX7
P2RY6
PAX5
PCED1A
PCSK5
PDE9A
PDIA4
PGAP6
PGLS
PHLDA1
PIGS
PIN1
PKD2
PLSCR4
POM121L8P
POU1F1
POU4F2
PRKAB2
PRPF31
PRR13
PRR19
PTGER3
PTK7
PTPMT1
PTPRH
PVR
QPRT
R3HDM2
RAB19
RAB3A
RALGDS
RANBP3
RASD1
RECK
RGL2
RHBDL1
RHNO1
RNF38
RNF8
RPS19BP1
RPS28
RTN4RL1
SCARF1
SCNM1
SEMA3B
SH3GLB2
SHFL
SLC13A5
SLC22A23
SLC23A1
SLC25A10
SLC25A31
SLC25A42
SLC6A20
SLIT1
SMARCE1
SMCP
SMG9
SMOC1
SPACA9
SPAG8
SPATA24
SPATA3
SPRY1
SPRY2
SSC4D
STK16
SUSD2
SUSD6
SUV39H1
TACSTD2
TAPBPL
TBC1D16
TBC1D23
TCAF1
TCEA2
TCEANC
TFAP2D
TGFB1
THAP10
THAP7
TIE1
TLE5
TMEM140
TMEM150A
TMIE
TNIP3
TNP2
TNPO3
TNS2
TRIM41
TRIM42
TRPV6
TSPAN4
TTC23
TXNDC5
TYMSOS
TYRO3
UBL5
UTP23
UXT
VASN
VENTX
VEZF1
VGLL3
VPS11
VWC2
VWC2L
WIF1
WNT11
WT1
WT1-AS
YIPF3
YY1
ZBTB24
ZBTB25
ZDHHC1
ZFYVE21
ZIC1
ZNF101
ZNF107
ZNF121
ZNF124
ZNF138
ZNF165
ZNF20
ZNF23
ZNF250
ZNF264
ZNF266
ZNF319
ZNF32
ZNF330
ZNF408
ZNF414
ZNF417
ZNF439
ZNF440
ZNF444
ZNF473
ZNF490
ZNF491
ZNF497
ZNF524
ZNF559
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF625
ZNF648
ZNF669
ZNF696
ZNF697
ZNF775
ZNF786
ZNF79
ZNF792
ZNF837
ZSCAN12
ZSCAN21
116 interacting genes:
ABL1
ABL2
ACTB
ADAM15
AGK
AGR2
APP
AR
ARRB1
ASAP1
BCAR1
BCR
BPIFA1
BTK
CBL
CCDC88B
CCR3
CD2AP
CHST15
CREBBP
CSF2RB
CSF3R
CSK
CTAG1A
CTAG1B
CYB5D2
CYSRT1
DNM2
DOK1
DOK2
EGFR
ELMO1
ERBB2
ERBB3
ERBB4
EVL
FASLG
FCGR1A
FCGR2A
FHL2
FHL5
GAB1
GOPC
GRB14
HNRNPK
HSF2BP
IL6ST
INCA1
INPP5D
IRF2BPL
KHDRBS1
KIT
KPRP
KRT31
KRT34
KRT35
KRT36
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-1
LCP2
LETMD1
LMNA
MAP4K5
MDK
MDM2
MET
MID2
MKRN3
MTUS2
NBPF19
NGEF
NOTCH2NLA
PAK2
PECAM1
PIK3CB
PIK3R1
PIK3R2
PLAUR
PLCG1
PLCG2
PLEKHG4
PNMA1
RAPGEF1
RASA1
RASA3
RBPMS
RPL10
SF3B3
SH2B2
SH3BP1
SH3KBP1
SKAP2
SOS1
SPRR2A
STAT3
TEKT4
TEPSIN
TNK2
TOX2
TP73
TRIM27
TRIP6
TRPV4
TSG101
UNC119
VAV1
WAS
WDCP
WIPF1
WNT2
ZSCAN4
Entrez ID
386681
3055
HPRD ID
11194
00796
Ensembl ID
ENSG00000187766
ENSG00000101336
Uniprot IDs
P60410
A8K4G3
P08631
PDB IDs
1AD5
1BU1
1QCF
2C0I
2C0O
2C0T
2HCK
2HK5
2OI3
2OJ2
3HCK
3NHN
3RBB
3REA
3REB
3VRY
3VRZ
3VS0
3VS1
3VS2
3VS3
3VS4
3VS5
3VS6
3VS7
4HCK
4LUD
4LUE
4ORZ
4U5W
5H09
5H0B
5H0E
5H0G
5H0H
5HCK
5NUH
5ZJ6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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