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KRTAP10-8 and EFEMP2
Data Source:
BioGRID
(two hybrid)
KRTAP10-8
EFEMP2
Description
keratin associated protein 10-8
EGF containing fibulin extracellular matrix protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Keratin Filament
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
Protein Binding
Identical Protein Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Keratinization
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Keratinization
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
388 interacting genes:
-
ACY3
ADAM12
ADAMTS1
ADAMTSL3
ADAMTSL4
AEBP2
AEN
AK3
ALDH3B1
ALPI
ALPP
AMMECR1
ANKS1A
AP1M1
APOL6
AQP1
AREG
ARID5A
ASPSCR1
ATG9A
ATP5F1D
AVPI1
AXIN2
BAHD1
BCL6B
BEX2
BMP7
BRME1
C10orf62
C11orf87
C17orf50
C19orf25
C22orf39
C2orf68
C3
CAMK1G
CARD10
CARHSP1
CATSPER1
CCDC26
CCNJL
CHIC2
CHRD
CHRNG
CLK4
CNNM3
COL8A1
COX17
CRCT1
CREB5
CRH
CRY2
CSF1
CTRC
CYP2S1
CYSRT1
DAAM2
DCX
DDX43
DDX55
DDX6
DERL2
DHRS1
DHX57
DMRT3
DOCK2
ECE1
EFEMP2
EIF4E2
ENKD1
EPDR1
FADS6
FAH
FAM110A
FAM161A
FAM221B
FAM27E3
FAM71C
FAM74A4
FAM76B
FAM90A1
FARS2
FBXO34
FBXW5
FEZF1
FOXB1
FRS3
FTHL17
FZD10
GEM
GFOD1
GLIDR
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GOLGA8EP
GPANK1
GPHB5
GPRIN2
GRN
GUCD1
HAPLN2
HCK
HHEX
HOXA1
HOXB5
HOXB9
HOXC8
HPCAL1
HS6ST1
HSD3B7
HSPA12B
HSPD1
ICAM1
IGFBP6
IGSF8
IL10
IL16
IL2RG
INO80B
INTS5
IP6K3
ITGB2
ITGB4
ITGB5
JOSD1
JPH3
KLHL38
KLK8
KPRP
KRT20
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP15-1
KRTAP17-1
KRTAP19-7
KRTAP3-1
KRTAP3-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LAGE3
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LELP1
LENG1
LINC00656
LMF2
LNX1
LRCH4
LRFN4
LUZP4
LYVE1
MACROH2A1
MAPKBP1
MATN3
MEIS2
MELTF
MEOX2
MLLT6
MOBP
MTA1
MUL1
MXI1
MYPOP
NAB2
NAXD
NBPF19
NECTIN2
NECTIN3
NEK6
NKD1
NOTCH2NLA
NPDC1
NR1D2
NR4A3
NTN4
NUFIP2
OLIG3
OPCML
OTX1
P2RX7
P2RY6
PAX5
PCED1A
PCSK5
PDE9A
PDIA4
PGAP6
PGLS
PHLDA1
PIGS
PIN1
PKD2
PLSCR4
POM121L8P
POU1F1
POU4F2
PRKAB2
PRPF31
PRR13
PRR19
PTGER3
PTK7
PTPMT1
PTPRH
PVR
QPRT
R3HDM2
RAB19
RAB3A
RALGDS
RANBP3
RASD1
RECK
RGL2
RHBDL1
RHNO1
RNF38
RNF8
RPS19BP1
RPS28
RTN4RL1
SCARF1
SCNM1
SEMA3B
SH3GLB2
SHFL
SLC13A5
SLC22A23
SLC23A1
SLC25A10
SLC25A31
SLC25A42
SLC6A20
SLIT1
SMARCE1
SMCP
SMG9
SMOC1
SPACA9
SPAG8
SPATA24
SPATA3
SPRY1
SPRY2
SSC4D
STK16
SUSD2
SUSD6
SUV39H1
TACSTD2
TAPBPL
TBC1D16
TBC1D23
TCAF1
TCEA2
TCEANC
TFAP2D
TGFB1
THAP10
THAP7
TIE1
TLE5
TMEM140
TMEM150A
TMIE
TNIP3
TNP2
TNPO3
TNS2
TRIM41
TRIM42
TRPV6
TSPAN4
TTC23
TXNDC5
TYMSOS
TYRO3
UBL5
UTP23
UXT
VASN
VENTX
VEZF1
VGLL3
VPS11
VWC2
VWC2L
WIF1
WNT11
WT1
WT1-AS
YIPF3
YY1
ZBTB24
ZBTB25
ZDHHC1
ZFYVE21
ZIC1
ZNF101
ZNF107
ZNF121
ZNF124
ZNF138
ZNF165
ZNF20
ZNF23
ZNF250
ZNF264
ZNF266
ZNF319
ZNF32
ZNF330
ZNF408
ZNF414
ZNF417
ZNF439
ZNF440
ZNF444
ZNF473
ZNF490
ZNF491
ZNF497
ZNF524
ZNF559
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF625
ZNF648
ZNF669
ZNF696
ZNF697
ZNF775
ZNF786
ZNF79
ZNF792
ZNF837
ZSCAN12
ZSCAN21
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
386681
30008
HPRD ID
11194
05221
Ensembl ID
ENSG00000187766
ENSG00000172638
Uniprot IDs
P60410
A0A024R5G1
O95967
Q9H3D5
PDB IDs
2KL7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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