KIF2A and CASK

Data Source:
BioGRID (two hybrid)

		KIF2A	CASK
Description		kinesin family member 2A	calcium/calmodulin dependent serine protein kinase
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Spindle Cytosol Kinesin Complex Microtubule Spindle Microtubule Membrane Nuclear Body Centriolar Subdistal Appendage	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Matrix Presynaptic Membrane Ciliary Membrane
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Microtubule Depolymerization Mitotic Spindle Organization Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Differentiation Regulation Of Cell Migration Cell Division Mitotic Spindle Assembly	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Neurotransmitter Secretion Negative Regulation Of Keratinocyte Proliferation GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs			Formic acid Fostamatinib
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Diastolic blood pressure ( 30224653) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CASK CLSTN1 DYNLT1 FAM13C FXR2 H3-4 KLC1 KLC2 LARP1B LMO2 LMO3 MRPL53 SUMO2	88 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L C20orf85 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DNAJC5 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE
Entrez ID		3796	8573
HPRD ID		03996	02164
Ensembl ID		ENSG00000068796	ENSG00000147044
Uniprot IDs		A0A6Q8PFA6 B0AZS5 O00139	A0A2R8Y6F8 A0A2R8YE77 O14936
PDB IDs		2GRY 6BBN	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH
Enriched GO Terms of Interacting Partners?
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