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KCNQ2 and CALM1
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
KCNQ2
CALM1
Description
potassium voltage-gated channel subfamily Q member 2
calmodulin 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Voltage-gated Potassium Channel Complex
Integral Component Of Membrane
Node Of Ranvier
Axon Initial Segment
Synapse
Spindle Pole
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Spindle Microtubule
Plasma Membrane
Voltage-gated Potassium Channel Complex
Sarcomere
Growth Cone
Synaptic Vesicle Membrane
Mitochondrial Membrane
Vesicle
Protein-containing Complex
Calcium Channel Complex
Myelin Sheath
Catalytic Complex
Molecular Function
Voltage-gated Potassium Channel Activity
Delayed Rectifier Potassium Channel Activity
Protein Binding
Calmodulin Binding
Ankyrin Binding
Calcium Ion Binding
Protein Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Calcium Channel Inhibitor Activity
Protein Kinase Binding
Protein Domain Specific Binding
Enzyme Regulator Activity
Nitric-oxide Synthase Regulator Activity
Titin Binding
Type 3 Metabotropic Glutamate Receptor Binding
N-terminal Myristoylation Domain Binding
Protein Serine/threonine Kinase Activator Activity
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Nitric-oxide Synthase Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
Biological Process
Chemical Synaptic Transmission
Nervous System Development
Regulation Of Ion Transmembrane Transport
Potassium Ion Transmembrane Transport
G2/M Transition Of Mitotic Cell Cycle
MAPK Cascade
Response To Amphetamine
Regulation Of Heart Rate
Platelet Degranulation
Detection Of Calcium Ion
Glycogen Catabolic Process
Muscle Contraction
G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Wnt Signaling Pathway, Calcium Modulating Pathway
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Viral Process
Substantia Nigra Development
Regulation Of Rhodopsin Mediated Signaling Pathway
Positive Regulation Of Protein Autophosphorylation
Regulation Of Cytokinesis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of DNA Binding
Inositol Phosphate Metabolic Process
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization To Mitochondrial Membrane
Regulation Of Cardiac Muscle Cell Action Potential
Regulation Of Synaptic Vesicle Endocytosis
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Voltage gated Potassium channels
Interaction between L1 and Ankyrins
CaMK IV-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
CaM pathway
Platelet degranulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
DARPP-32 events
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
Calcineurin activates NFAT
eNOS activation
Transcriptional activation of mitochondrial biogenesis
Inactivation, recovery and regulation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Smooth Muscle Contraction
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Negative regulation of NMDA receptor-mediated neuronal transmission
Activation of RAC1 downstream of NMDARs
Activation of RAC1 downstream of NMDARs
Activation of AMPK downstream of NMDARs
Long-term potentiation
Long-term potentiation
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Enflurane
Amitriptyline
Meclofenamic acid
Promethazine
Miconazole
Ezogabine
ICA-105665
Chlorpromazine
Cinchocaine
Nicardipine
Fluphenazine
Isoflurane
Trifluoperazine
Loperamide
Perphenazine
Phenoxybenzamine
Felodipine
Melatonin
Promethazine
Pimozide
Nifedipine
Bepridil
Calcium
Aprindine
Deacetoxyvinzolidine
tert-butanol
Trimethyllysine
N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Prenylamine
Flunarizine
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE
Myristic acid
Calcium citrate
Calcium citrate
Calcium citrate
Calcium Phosphate
Calcium Phosphate
Calcium Phosphate
Calcium levulinate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Perceived intensity of neohesperidin dihydrochalcone (
31005972
)
Leukocyte telomere length (
32109421
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Interacting Genes
6 interacting genes:
ARIH2
CALM1
CALM2
CALM3
KCNQ3
PRKCA
261 interacting genes:
ACADM
ACE2
ADCY8
ADCYAP1R1
ADD1
ADD2
AKAP5
AKAP6
AKAP9
AR
ARHGEF7
ARMC1
ASCL2
ATP2B1
ATRX
BRWD1
C11orf65
C4orf3
CABIN1
CALCR
CALD1
CAMK1
CAMK2G
CAMKK1
CAMKK2
CAMTA2
CASP8AP2
CCDC14
CCNA2
CCND1
CCND2
CCNE1
CCP110
CDC37L1
CDC5L
CKMT1B
CLINT1
CLIP1
CLTB
CNGA2
CNN1
CRHR1
CSNK2A1
CSNK2A2
CSNK2B
DAPK1
DCTN2
DCUN1D1
DDAH1
DDIT4L
DDX21
DDX5
DLG3
DMXL1
DNAJC13
DOCK11
DOCK3
DRD2
DST
EDF1
EGFR
EIF3C
ERBB2
ERBB3
ESR1
ESR2
ESRRG
EWSR1
FAS
FBXO9
FER
FKBP3
FKBP4
GAP43
GCLM
GEM
GJB1
GLP1R
GLP2R
GNAS
GRB7
GRIN1
GRK1
GRK4
GRK5
GRM3
GRM4
GRM5
GRM7
GSC2
GTF2I
H2AX
HERC2
HMMR
HSP90AA1
HSPA4
HTR2C
HUWE1
IDH1
IMMT
INSR
IQCE
IQCG
IQCN
IQGAP1
IQGAP2
ITGA6
ITPKA
ITPKB
KCNB1
KCNH1
KCNN1
KCNN2
KCNN3
KCNN4
KCNQ2
KCNQ3
KCNQ5
KDM5C
KIF1B
KRAS
LACTB
LINC00839
LMO7
LTF
LUC7L
LY96
LYST
MAPT
MATR3
MBIP
METAP2
MFHAS1
MIP
MORF4L1
MYBPC1
MYC
MYCBP2
MYF5
MYF6
MYLK
MYO10
MYO5A
MYO7A
MYO9B
MYOD1
MYOG
NBR1
NEB
NEUROD1
NEXN
NOL7
NOS3
NR3C1
NRGN
NSMF
NT5C2
OBSCN
OPALIN
OPRM1
OPTN
PAM
PCNT
PCP4
PDCD7
PDE1A
PHACTR4
PHKB
PHKG1
PIK3C3
PLA2G6
PLCD1
POC5
POLR2B
PPEF1
PPEF2
PPIL2
PRDX1
PSMD12
PSMD2
PTAFR
PTEN
PTH2R
PTPRA
PUM3
RAB3B
RAD23B
RALA
RALB
RANBP2
RDX
REL
RELA
RGS10
RGS2
RGS4
RIT2
RPL13A
RPL22
RPS14
RPS15A
RPS4Y1
RPS8
RRAD
RS1
RYR1
S100B
SCAPER
SCLT1
SCN4A
SCN5A
SCTR
SDCBP
SEC61A1
SET
SF3B1
SLF2
SLTM
SNCA
SNRPB2
SNTA1
SNX6
SPATA17
SPP1
SQSTM1
SRP14
SRSF5
STAG1
STIM2
STK38
STRN
STRN3
STRN4
STX8
SUMO2
SYK
SYNE2
SYT1
TBC1D1
TCF3
TCF4
THOP1
TNNI2
TPT1
TRDN
TRPC3
TRPV1
TRPV4
TRPV6
TSC2
TTN
UBR4
UCHL5
USP16
UTRN
VIPR1
XRCC4
YBX1
YWHAE
ZBTB24
ZNF280A
Entrez ID
3785
801
HPRD ID
03757
00241
Ensembl ID
ENSG00000075043
ENSG00000198668
Uniprot IDs
O43526
Q53Y30
B4DJ51
P0DP23
P0DP24
P0DP25
PDB IDs
5J03
6FEG
6FEH
7CR0
7CR1
7CR2
7CR3
7CR4
7CR7
1AJI
1CDL
1CLL
1CTR
1IWQ
1J7O
1J7P
1K90
1K93
1L7Z
1LVC
1NKF
1PK0
1S26
1SK6
1SW8
1UP5
1WRZ
1XFU
1XFV
1XFW
1XFX
1XFY
1XFZ
1Y6W
1YR5
1YRT
1YRU
1ZOT
1ZUZ
2BE6
2F3Y
2F3Z
2HF5
2I08
2JZI
2K0E
2K0F
2K0J
2K61
2KNE
2KUG
2KUH
2L53
2L7L
2LGF
2LL6
2LL7
2LQC
2LQP
2LV6
2M0J
2M0K
2M55
2MG5
2N27
2N6A
2N77
2N8J
2R28
2V01
2V02
2VAY
2W73
2WEL
2X0G
2Y4V
3BYA
3DVE
3DVJ
3DVK
3DVM
3EWT
3EWV
3G43
3HR4
3J41
3O77
3O78
3OXQ
3SUI
3UCT
3UCW
3UCY
4BW7
4BW8
4BYF
4DCK
4DJC
4GOW
4JPZ
4JQ0
4L79
4LZX
4M1L
4OVN
4Q57
4Q5U
4UMO
4UPU
4V0C
5COC
5DBR
5DOW
5DSU
5GGM
5I0I
5J03
5J8H
5JQA
5JTH
5K7L
5K8Q
5NIN
5OEO
5TP5
5TP6
5V02
5V03
5V7X
5VMS
5WBX
5WC5
5WSU
5WSV
6B8L
6B8M
6B8N
6B8P
6B8Q
6BUT
6C1D
6C1G
6C1H
6CNM
6CNN
6CNO
6DAD
6DAE
6DAF
6DAH
6E2F
6E2G
6EEB
6FEG
6FEH
6GDK
6GDL
6HCS
6HR1
6JI8
6JII
6JIU
6JIY
6JRS
6JV2
6K4K
6K4L
6K4R
6K67
6M2W
6M7H
6MUD
6MUE
6N5W
6O5G
6OS4
6PAW
6PBX
6PBY
6PLM
6S5T
6SZ5
6U39
6U3A
6U3B
6U3D
6UZZ
6V00
6V01
6Y4O
6Y4P
6Y94
6Y95
7CR3
7CR4
7CR7
Enriched GO Terms of Interacting Partners
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