ITGAD and SHARPIN

Data Source:
BioGRID (unspecified method)

		ITGAD	SHARPIN
Description		integrin subunit alpha D	SHANK associated RH domain interactor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex
	Molecular Function	Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Immune Response Integrin-mediated Signaling Pathway Extracellular Matrix Organization Heterotypic Cell-cell Adhesion	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Integrin cell surface interactions	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		4 interacting genes: ICAM3 ITGB2 SHARPIN VCAM1	21 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32
Entrez ID		3681	81858
HPRD ID		11785	15463
Ensembl ID		ENSG00000156886	ENSG00000179526
Uniprot IDs		Q13349 Q59H14	Q6PJD5 Q9H0F6
PDB IDs			4EMO 5X0W
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?