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IRF7 and TRMT61B
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
IRF7
TRMT61B
Description
interferon regulatory factor 7
tRNA methyltransferase 61B
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Mitochondrion
Mitochondrial Matrix
TRNA (m1A) Methyltransferase Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
TRNA (adenine-N1-)-methyltransferase Activity
RRNA (adenine) Methyltransferase Activity
MRNA (adenine-N1-)-methyltransferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Adaptive Immune Response
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Response To Virus
Immunoglobulin Mediated Immune Response
Establishment Of Viral Latency
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Interferon-alpha Production
Interferon-beta Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Innate Immune Response
Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Immune Response
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Macrophage Apoptotic Process
TRNA Methylation
RRNA Methylation
Protein Homooligomerization
Mitochondrial TRNA Methylation
MRNA Methylation
Pathways
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
tRNA modification in the mitochondrion
Drugs
Diseases
GWAS
Systemic lupus erythematosus (
27399966
26502338
28714469
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
31672989
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Intraocular pressure (
29617998
)
Interacting Genes
27 interacting genes:
ACADS
AIP
ARAF
CCDC47
CREBBP
EP300
GCLM
INSR
IRAK1
IRF3
KAT2A
KAT2B
LTN1
MAVS
MYD88
PALD1
PIAS4
SOCS1
SOCS3
TBK1
TICAM1
TICAM2
TLK2
TP53
TRAF6
TRIM28
TRMT61B
3 interacting genes:
FAM9B
IRF7
PPP2CB
Entrez ID
3665
55006
HPRD ID
05441
07935
Ensembl ID
ENSG00000185507
ENSG00000171103
Uniprot IDs
A0A024RCA2
B4E1B1
M9RSF4
Q92985
Q9BVS5
PDB IDs
2O61
2B25
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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