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IRF7 and GCLM
Data Source:
BioGRID
(two hybrid)
IRF7
GCLM
Description
interferon regulatory factor 7
glutamate-cysteine ligase modifier subunit
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Cytosol
Glutamate-cysteine Ligase Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Sequence-specific Double-stranded DNA Binding
Glutamate-cysteine Ligase Activity
Protein Binding
Enzyme Regulator Activity
Glutamate-cysteine Ligase Catalytic Subunit Binding
Protein-containing Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Adaptive Immune Response
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Response To Virus
Immunoglobulin Mediated Immune Response
Establishment Of Viral Latency
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Interferon-alpha Production
Interferon-beta Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Innate Immune Response
Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Immune Response
Defense Response To Virus
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Macrophage Apoptotic Process
Cysteine Metabolic Process
Glutamate Metabolic Process
Glutathione Biosynthetic Process
Response To Oxidative Stress
Aging
Response To Nutrient
Apoptotic Mitochondrial Changes
Response To Activity
Positive Regulation Of Glutamate-cysteine Ligase Activity
Cellular Response To Hepatocyte Growth Factor Stimulus
Hepatic Stellate Cell Activation
Response To Drug
Negative Regulation Of Neuron Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Human Chorionic Gonadotropin
Response To Nitrosative Stress
Regulation Of Mitochondrial Depolarization
Cellular Response To Glucose Stimulus
Cellular Response To Follicle-stimulating Hormone Stimulus
Cellular Response To Thyroxine Stimulus
Blood Vessel Diameter Maintenance
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Glutathione synthesis and recycling
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Drugs
Glutamic acid
Cysteine
Diseases
GWAS
Systemic lupus erythematosus (
27399966
26502338
28714469
)
Systemic lupus erythematosus and Systemic sclerosis (
23740937
)
Systemic sclerosis (
31672989
)
Metabolite levels (
23823483
)
Ovarian cancer (
30557369
)
Refractive error (
32231278
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
27 interacting genes:
ACADS
AIP
ARAF
CCDC47
CREBBP
EP300
GCLM
INSR
IRAK1
IRF3
KAT2A
KAT2B
LTN1
MAVS
MYD88
PALD1
PIAS4
SOCS1
SOCS3
TBK1
TICAM1
TICAM2
TLK2
TP53
TRAF6
TRIM28
TRMT61B
4 interacting genes:
CALM1
IRF7
OSGIN1
STOX1
Entrez ID
3665
2730
HPRD ID
05441
03106
Ensembl ID
ENSG00000185507
ENSG00000023909
Uniprot IDs
A0A024RCA2
B4E1B1
M9RSF4
Q92985
P48507
PDB IDs
2O61
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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