INPPL1 and ARAP3

Data Source:
BioGRID (pull down, pull down)

		INPPL1	ARAP3
Description		inositol polyphosphate phosphatase like 1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium	Ruffle Cytosol Cytoskeleton Plasma Membrane Lamellipodium
	Molecular Function	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Response To Insulin Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling	Rho GTPase cycle
Drugs
Diseases
GWAS		Heart rate response to recovery post exercise (10 sec) ( 29497042)	Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		21 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 MET SHC1 SORBS1 SORBS3 SRC UBC	10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2
Entrez ID		3636	64411
HPRD ID		02900	09441
Ensembl ID		ENSG00000165458	ENSG00000120318
Uniprot IDs		O15357	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP	2KG5 2LNW 5JCP 5JD0 7A9B
Enriched GO Terms of Interacting Partners?
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