ING1 and NQO1

Data Source:
HPRD (in vivo)

		ING1	NQO1
Description		inhibitor of growth family member 1	NAD(P)H quinone dehydrogenase 1
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GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Dendrite Neuronal Cell Body Synapse
	Molecular Function	Protein Binding Methylated Histone Binding Metal Ion Binding	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Cell Death Negative Regulation Of Cell Growth Positive Regulation Of Transcription, DNA-templated	Response To Ischemia NADH Oxidation Regulation Of Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Toxic Substance Response To Hormone Response To Carbohydrate Response To Amine Removal Of Superoxide Radicals Response To Estradiol Response To Testosterone Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Response To Ethanol Response To Electrical Stimulus Cellular Response To Hydrogen Peroxide NADPH Oxidation Cellular Response To Metal Ion Response To Tetrachloromethane Response To L-glutamine Response To Hydrogen Sulfide Response To Flavonoid
Pathways			Regulation of ornithine decarboxylase (ODC)
Drugs			Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Blood protein levels ( 30072576) Erosive tooth wear (severe vs non-severe) ( 29898447)	Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		29 interacting genes: BRMS1 BRMS1L COPS2 CYTOR DMAP1 EP300 ESR1 EXOC4 H3C14 HDAC1 HDAC2 KAT2B MRGBP NQO1 PCNA RBBP4 RBBP7 RBP1 SAP30 SFN SIN3A TP53 UBC YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	9 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 STUB1 TP53 UBE2D1
Entrez ID		3621	1728
HPRD ID		03337	00518
Ensembl ID		ENSG00000153487	ENSG00000181019
Uniprot IDs		A0A0C4DFW2 Q9UK53	B4DLR8 P15559
PDB IDs		2QIC	1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4
Enriched GO Terms of Interacting Partners?
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