IGKC and CD40LG

Data Source:
HPRD (in vitro)

		IGKC	CD40LG
Description		immunoglobulin kappa constant	CD40 ligand
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Antigen Binding Immunoglobulin Receptor Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding
	Biological Process	Retina Homeostasis Immunoglobulin Production Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Innate Immune Response Regulation Of Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Ruplizumab
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS			CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		4 interacting genes: CD40LG IGHG1 MLH1 SMARCD1	6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		3514	959
HPRD ID		00921	02311
Ensembl ID		ENSG00000211592	ENSG00000102245
Uniprot IDs			P29965
PDB IDs			1ALY 1I9R 3LKJ 3QD6 6BRB
Enriched GO Terms of Interacting Partners?
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