JCHAIN and IGHM

Data Source:
HPRD (in vitro)

		JCHAIN	IGHM
Description		joining chain of multimeric IgA and IgM	immunoglobulin heavy constant mu
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Antigen Binding IgA Binding Protein-macromolecule Adaptor Activity Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding	Single-stranded DNA Binding Antigen Binding Protein Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Retina Homeostasis Adaptive Immune Response Glomerular Filtration Receptor-mediated Endocytosis Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Leukocyte Migration Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration
Pathways		Cell surface interactions at the vascular wall Scavenging of heme from plasma
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS
Interacting Genes		2 interacting genes: CD79A IGHM	19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3
Entrez ID		3512	3507
HPRD ID		00991	00912
Ensembl ID		ENSG00000132465	ENSG00000211899
Uniprot IDs		P01591
PDB IDs		6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA
Enriched GO Terms of Interacting Partners?
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