IGFBP5 and SLC38A1

Data Source:
BioGRID (two hybrid)

		IGFBP5	SLC38A1
Description		insulin like growth factor binding protein 5	solute carrier family 38 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Neuronal Cell Body Extracellular Exosome External Side Of Apical Plasma Membrane
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Amino Acid:sodium Symporter Activity Neutral Amino Acid:sodium Symporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Neurotransmitter Uptake Amino Acid Transmembrane Transport Sodium Ion Transport Amino Acid Transport Glutamine Transport Neutral Amino Acid Transport L-amino Acid Transport Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Astrocytic Glutamate-Glutamine Uptake And Metabolism Amino acid transport across the plasma membrane
Drugs			Asparagine
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Visceral fat ( 22589738)	Birth weight ( 31043758) Gout ( 32238385) Morning person ( 30696823) Offspring birth weight ( 31043758) Refractive error ( 32231278)
Interacting Genes		92 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ASGR1 BAG6 BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CREB3 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FHL1 FHL2 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MFSD5 MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SERPINE1 SLC10A6 SLC13A4 SLC38A1 SLC41A2 SLC41A3 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN	30 interacting genes: AMIGO1 AQP6 BMP10 C1QL4 CD79A CREB3 FATE1 FFAR2 GPR152 GPR42 GRM2 IGFBP5 IL1RL1 PDCD1LG2 PGRMC2 PMP22 PTPN11 RPRM SCGB1D1 SCN3B SERP2 SLC10A1 SLC10A6 SLC13A4 SMIM3 SSMEM1 STRIT1 TMEM60 TMPPE TRARG1
Entrez ID		3488	81539
HPRD ID		00901	12245
Ensembl ID		ENSG00000115461	ENSG00000111371
Uniprot IDs		P24593	A0A024R124 F8VX04 Q9H2H9
PDB IDs		1BOE 1H59
Enriched GO Terms of Interacting Partners?
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