IGFBP5 and FNDC9

Data Source:
BioGRID (two hybrid)

		IGFBP5	FNDC9
Description		insulin like growth factor binding protein 5	fibronectin type III domain containing 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Protein Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Aging Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Cellular Response To Organic Cyclic Compound Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Breast cancer ( 29059683) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Height ( 31562340) Hypothyroidism ( 27182965) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Mitral valve prolapse ( 26301497) Pulse pressure ( 27841878) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Visceral fat ( 22589738)	Asthma ( 31959851)
Interacting Genes		92 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ASGR1 BAG6 BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CREB3 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FHL1 FHL2 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MFSD5 MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SERPINE1 SLC10A6 SLC13A4 SLC38A1 SLC41A2 SLC41A3 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN	88 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 AQP1 ASGR1 ATXN1 BMP10 C1QL4 C3orf52 CLDN1 CLDN11 CLDN19 CLEC1A CLEC2D CLEC7A CLN6 CLRN2 CMTM5 CNIH3 COL8A2 CTSA CXCL16 CXCL9 CYB5B DEFB132 DOLK EDDM3B EMP3 ENTPD3 ERMP1 EXTL1 GALNT15 GCNT2 HHATL IGFBP5 ITM2A ITM2C JAGN1 KRTCAP3 LHFPL5 LPAR3 MAL MALL MOSPD3 NINJ1 NINJ2 NKG7 NSG1 OLFM4 PGA4 PGAP2 PLLP PLN PLP1 PLP2 PLPP6 PROKR2 RPRM SEC22B SERP2 SFTPC SLC35A1 SLC41A2 SMIM1 SMIM3 ST6GAL2 STX8 TMEM100 TMEM140 TMEM182 TMEM254 TMEM60 TMEM79 TMEM86A TMPRSS4 TNF TRARG1 TREX1 TSPO2 TWSG1 UBIAD1 UPK1B UPK2 VAMP5 VSTM1 ZDHHC22 ZFPL1
Entrez ID		3488	408263
HPRD ID		00901	17524
Ensembl ID		ENSG00000115461	ENSG00000172568
Uniprot IDs		P24593	Q8TBE3
PDB IDs		1BOE 1H59
Enriched GO Terms of Interacting Partners?
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