IRGM and ATG5

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IRGM	ATG5
Description		immunity related GTPase M	autophagy related 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding	Protein Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation By Symbiont Of Host Autophagy Cellular Response To Virus Positive Regulation Of Autophagosome Maturation	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Production Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Fungus Macroautophagy Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Response To Drug Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Positive Regulation By Symbiont Of Host Autophagy Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation
Pathways			Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: ATG10 ATG5 MAP1LC3C NOD2 SH3GLB1	28 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCDC12 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 OPTN PSMB11 RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3
Entrez ID		345611	9474
HPRD ID		19559	16051
Ensembl ID		ENSG00000237693	ENSG00000057663
Uniprot IDs		A1A4Y4	A9UGY9 Q7Z3H3 Q9H1Y0
PDB IDs			4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW
Enriched GO Terms of Interacting Partners?
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