IRGM and SH3GLB1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IRGM	SH3GLB1
Description		immunity related GTPase M	SH3 domain containing GRB2 like, endophilin B1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection	Golgi Membrane Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Cytosol Midbody Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein-containing Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation By Symbiont Of Host Autophagy Cellular Response To Virus Positive Regulation Of Autophagosome Maturation	Autophagy Apoptotic Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Autophagic Cell Death Membrane Fission Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Autophagosome Assembly
Pathways
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		5 interacting genes: ATG10 ATG5 MAP1LC3C NOD2 SH3GLB1	52 interacting genes: ABHD5 ADAM15 ADAM9 AGTRAP AMPH APP ARFIP2 ARHGAP17 BAX BIN1 C1D CACFD1 CDKN2D CMTM5 COQ8A DESI2 DNM2 EXOSC5 F8A1 FAM114A2 FN1 FUNDC1 GADD45A GADD45G GSTP1 HTATIP2 HTT IRGM ITGB1BP2 MAL2 MTA1 PSMA1 RABAC1 RABGGTB RHEX RIC8A SH3GLB2 SH3KBP1 SIN3A SMIM5 SNX1 SNX4 SYNGR3 SYNJ1 SYP TAX1BP1 TFIP11 TPD52 TPD52L2 TTN UBL7 ZNF576
Entrez ID		345611	51100
HPRD ID		19559	15333
Ensembl ID		ENSG00000237693	ENSG00000097033
Uniprot IDs		A1A4Y4	A0A087WW40 A0A140VJU5 Q9Y371
PDB IDs			6UP6 6UPN
Enriched GO Terms of Interacting Partners?
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