KRTAP8-1 and CCNK

Data Source:
BioGRID (two hybrid)

		KRTAP8-1	CCNK
Description		keratin associated protein 8-1	cyclin K
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex
	Molecular Function	Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Keratinization	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Serine 2 Residues
Pathways		Keratinization	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		78 interacting genes: AANAT AGXT AOC1 ARID5A ATG9A ATXN1L BANP BCAS2 BHLHE40 C11orf16 C1orf94 C20orf85 CAMK2A CCDC17 CCNK CDA CERCAM CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRTB1 DTX2 FAAP20 FAM168A FAM83A FOXD2 FOXP3 GATA2 GCM2 GLIS2 HEY2 HOXC8 HYPK KRTAP12-4 KRTAP19-5 KRTAP26-1 MFSD13A MKRN3 MYOZ3 NKX2-5 NOXA1 P4HA3 PAX3 PITX1 PLSCR4 POGZ POU6F2 PPP1R32 PROP1 PRR13 PRR35 PSMA3 RAMAC RBPMS RBPMS2 RNF38 RUSC1 SMR3A SMUG1 SNRPC TBX18 TEKT3 TIAL1 TLE5 TLX3 TMSB4X TNIP1 TNPO2 TSPYL6 VENTX VEZF1 YTHDF1 ZBTB32 ZC3H10 ZIC1 ZNF34	52 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446
Entrez ID		337879	8812
HPRD ID		11221	10352
Ensembl ID		ENSG00000183640	ENSG00000090061
Uniprot IDs		Q8IUC2	A0A024R6K1 O75909
PDB IDs			2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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