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HSP90AA1 and EIF2AK3
Data Source:
HPRD
(in vivo)
HSP90AA1
EIF2AK3
Description
heat shock protein 90 alpha family class A member 1
eukaryotic translation initiation factor 2 alpha kinase 3
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Membrane
Protein-containing Complex
Secretory Granule Lumen
Melanosome
Neuronal Cell Body
Lysosomal Lumen
Myelin Sheath
Dendritic Growth Cone
Axonal Growth Cone
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Endocytic Vesicle Lumen
Ficolin-1-rich Granule Lumen
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
MHC Class II Protein Complex Binding
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Protein Folding Chaperone
Tau Protein Binding
GTPase Binding
Unfolded Protein Binding
DNA Polymerase Binding
Scaffold Protein Binding
Disordered Domain Specific Binding
Protein Tyrosine Kinase Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Protein Phosphatase Binding
Identical Protein Binding
Hsp90 Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Protein Folding
Mitochondrial Transport
Receptor-mediated Endocytosis
Response To Unfolded Protein
Telomere Maintenance Via Telomerase
Response To Heat
Response To Cold
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Cytokine-mediated Signaling Pathway
Central Nervous System Neuron Axonogenesis
Establishment Of Cell Polarity
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Polymerization
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Heat
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Protein Refolding
Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Neutrophil Degranulation
Protein Unfolding
Protein Insertion Into Mitochondrial Outer Membrane
Positive Regulation Of Nitric Oxide Biosynthetic Process
Response To Antibiotic
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Axon Extension
Protein Stabilization
Regulation Of Nitric-oxide Synthase Activity
Chaperone-mediated Protein Complex Assembly
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Telomerase Activity
Chaperone-mediated Autophagy
Ciliary Basal Body-plasma Membrane Docking
Cellular Response To Virus
Regulation Of Cellular Response To Heat
Positive Regulation Of Tau-protein Kinase Activity
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Cellular Protein Localization
Telomerase Holoenzyme Complex Assembly
Skeletal System Development
Ossification
Angiogenesis
Chondrocyte Development
Protein Phosphorylation
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
ER Overload Response
Endoplasmic Reticulum Organization
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-serine Phosphorylation
Calcium-mediated Signaling
Bone Mineralization
Endoplasmic Reticulum Unfolded Protein Response
Endocrine Pancreas Development
Negative Regulation Of Myelination
Negative Regulation Of Translational Initiation In Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Cellular Response To Cold
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Response To Manganese-induced Endoplasmic Reticulum Stress
Pathways
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
vRNP Assembly
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
Scavenging by Class F Receptors
Scavenging by Class F Receptors
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Uptake and function of diphtheria toxin
PIWI-interacting RNA (piRNA) biogenesis
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Downregulation of ERBB2 signaling
ESR-mediated signaling
Extra-nuclear estrogen signaling
RHOBTB2 GTPase cycle
Estrogen-dependent gene expression
Chaperone Mediated Autophagy
Constitutive Signaling by Overexpressed ERBB2
Aggrephagy
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Potential therapeutics for SARS
PERK regulates gene expression
Drugs
Rifabutin
Nedocromil
9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
Geldanamycin
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine
9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
Quercetin
8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
Tanespimycin
SNX-5422
N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE
5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol
CCT-018159
4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
Copper
Polaprezinc
Alvespimycin
Diseases
Wolcott-Rallison syndrome; SED, Wolcott-Rallison type
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Adverse response to drug (
30420678
)
Appendicular lean mass (
33097823
)
Chronotype (
30696823
)
Height (
20881960
25282103
25429064
31562340
)
Progressive supranuclear palsy (
21685912
)
Interacting Genes
158 interacting genes:
AHR
AHSA1
AHSA2P
AIP
AIPL1
AKT1
AKT2
APAF1
APOB
AR
ARNTL
ASGR1
BIRC5
BRMS1
CACYBP
CALM1
CDC37
CDC37L1
CDK4
CDK5R1
CDKN2A
CERS2
CFTR
CHEK1
CHORDC1
CHUK
CKS1B
CKS2
CRNKL1
CSNK2A1
CSNK2A2
DAP3
DNAJC7
EGFR
EGLN1
EIF2AK1
EIF2AK2
EIF2AK3
EIF2S1
EPAS1
EPRS1
ERBB2
ERN1
ESR1
ESRRB
FAM162A
FANCA
FANCC
FKBP1A
FKBP4
FKBP5
FKBP6
FLCN
FNIP1
FYN
GABARAPL1
GNA12
GSK3B
GUCY1B1
GZMA
HDAC6
HIF1A
HIF3A
HSF1
HSPA8
HTT
IKBKB
IKBKE
IKBKG
IP6K2
IRAK1
IRF3
ITGB1BP2
JUN
KDR
KEAP1
LCK
LINC01554
LSM1
MAP3K14
MAP3K3
MAPK1
MAPT
MIS12
MMP2
MS4A2
MTRNR2L1
MUC1
MYC
MYOD1
NDRG1
NOS1
NOS3
NPAS2
NR2C2
NR3C1
NR3C2
NSL1
PABPN1
PAK1
PDPK1
PIM1
PMF1
PPARA
PPARD
PPID
PPIL2
PPP5C
PRKACA
PRKCA
PRKCD
PRKDC
PTGDS
PTGES3
PTPRF
RAD51
RAF1
RHOBTB2
RIPK1
RPAP3
RPS3
RPS3A
RUNX1T1
SERPINB5
SGTA
SIM1
SKP1
SLC2A4
SLC34A1
SMYD2
SMYD3
SNCA
SRC
ST13
STARD13
STAT3
STIP1
STUB1
SUGT1
SUMO2
SVIL
TBK1
TERT
TJP1
TNFRSF1A
TOMM34
TOMM40
TOMM70
TP53
TTK
TTR
UBASH3A
UBE2N
UCHL1
UNC45A
USP19
USP50
WASL
6 interacting genes:
DNAJC3
EIF2S1
HSP90AA1
HSPA5
IKBKB
NFE2L2
Entrez ID
3320
9451
HPRD ID
00777
04942
Ensembl ID
ENSG00000080824
ENSG00000172071
Uniprot IDs
K9JA46
P07900
Q86SX1
B3KY45
Q68DI6
Q9NZJ5
PDB IDs
1BYQ
1OSF
1UY6
1UY7
1UY8
1UY9
1UYC
1UYD
1UYE
1UYF
1UYG
1UYH
1UYI
1UYK
1UYL
1YC1
1YC3
1YC4
1YER
1YES
1YET
2BSM
2BT0
2BUG
2BYH
2BYI
2BZ5
2C2L
2CCS
2CCT
2CCU
2FWY
2FWZ
2H55
2JJC
2K5B
2QF6
2QFO
2QG0
2QG2
2UWD
2VCI
2VCJ
2WI1
2WI2
2WI3
2WI4
2WI5
2WI6
2WI7
2XAB
2XDK
2XDL
2XDS
2XDU
2XDX
2XHR
2XHT
2XHX
2XJG
2XJJ
2XJX
2XK2
2YE2
2YE3
2YE4
2YE5
2YE6
2YE7
2YE8
2YE9
2YEA
2YEB
2YEC
2YED
2YEE
2YEF
2YEG
2YEH
2YEI
2YEJ
2YI0
2YI5
2YI6
2YI7
2YJW
2YJX
2YK2
2YK9
2YKB
2YKC
2YKE
2YKI
2YKJ
3B24
3B25
3B26
3B27
3B28
3BM9
3BMY
3D0B
3EKO
3EKR
3FT5
3FT8
3HEK
3HHU
3HYY
3HYZ
3HZ1
3HZ5
3INW
3INX
3K97
3K98
3K99
3MNR
3O0I
3OW6
3OWB
3OWD
3Q6M
3Q6N
3QDD
3QTF
3R4M
3R4N
3R4O
3R4P
3R91
3R92
3RKZ
3RLP
3RLQ
3RLR
3T0H
3T0Z
3T10
3T1K
3T2S
3TUH
3VHA
3VHC
3VHD
3WHA
3WQ9
4AIF
4AWO
4AWP
4AWQ
4B7P
4BQG
4BQJ
4CGQ
4CGU
4CGV
4CGW
4CWF
4CWN
4CWO
4CWP
4CWQ
4CWR
4CWS
4CWT
4EEH
4EFT
4EFU
4EGH
4EGI
4EGK
4FCP
4FCQ
4FCR
4HY6
4JQL
4L8Z
4L90
4L91
4L93
4L94
4LWE
4LWF
4LWG
4LWH
4LWI
4NH7
4NH8
4O04
4O05
4O07
4O09
4O0B
4R3M
4U93
4W7T
4XIP
4XIQ
4XIR
4XIT
4YKQ
4YKR
4YKT
4YKU
4YKW
4YKX
4YKY
4YKZ
5CF0
5FNC
5FND
5FNF
5GGZ
5J20
5J27
5J2V
5J2X
5J64
5J6L
5J6M
5J6N
5J80
5J82
5J86
5J8M
5J8U
5J9X
5LNY
5LNZ
5LO0
5LO1
5LO5
5LO6
5LQ9
5LR1
5LR7
5LRL
5LRZ
5LS1
5M4E
5M4H
5NYH
5NYI
5OCI
5OD7
5ODX
5T21
5VYY
5XQD
5XQE
5XR5
5XR9
5XRB
5XRD
5XRE
5ZR3
6B99
6B9A
6CEO
6CYG
6CYH
6EI5
6EL5
6ELN
6ELO
6ELP
6EY8
6EY9
6EYA
6EYB
6F1N
6FCJ
6FDP
6GP4
6GP8
6GPF
6GPH
6GPO
6GPP
6GPR
6GPT
6GPW
6GPY
6GQ6
6GQR
6GQS
6GQU
6GR1
6GR3
6GR4
6GR5
6HHR
6KSQ
6N8X
6OLX
6TN4
6TN5
6U98
6U99
6U9A
6U9B
4G31
4G34
4M7I
4X7H
4X7J
4X7K
4X7L
4X7N
4X7O
4YZS
5SV7
Enriched GO Terms of Interacting Partners
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