EIF2AK3 and HSPA5

Data Source:
HPRD (in vivo)

		EIF2AK3	HSPA5
Description		eukaryotic translation initiation factor 2 alpha kinase 3	heat shock protein family A (Hsp70) member 5
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Cold Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress	Luteolysis ER Overload Response Positive Regulation Of Neuron Projection Development Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cell Migration Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Posttranslational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Cellular Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Drug IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Protein Refolding Cellular Response To Glucose Starvation Response To Cocaine Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Neuron Apoptotic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Calcium Ion Cellular Response To Manganese Ion Cellular Response To CAMP Cellular Response To Interleukin-4 Cellular Response To Gamma Radiation Stress Response To Metal Ion Toxin Transport Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Response To Methamphetamine Hydrochloride Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		PERK regulates gene expression	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases		Wolcott-Rallison syndrome; SED, Wolcott-Rallison type Permanent neonatal diabetes mellitus (PNDM)
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Progressive supranuclear palsy ( 21685912)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2	70 interacting genes: A2M APC APOB BAG3 BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DNAJC3 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HMGB1 HSPB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 OTUD3 PARK7 PAWR PCSK7 PRNP PSME3 PTPN11 PTPRF RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF YWHAB
Entrez ID		9451	3309
HPRD ID		04942	00682
Ensembl ID		ENSG00000172071	ENSG00000044574
Uniprot IDs		B3KY45 Q68DI6 Q9NZJ5	P11021 V9HWB4
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7	3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS
Enriched GO Terms of Interacting Partners?
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