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HMOX2 and CCR2
Data Source:
BioGRID
(two hybrid)
HMOX2
CCR2
Description
heme oxygenase 2
C-C motif chemokine receptor 2
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Specific Granule Membrane
Cytoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
Heme Oxygenase (decyclizing) Activity
Protein Binding
Heme Binding
Metal Ion Binding
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
CCR2 Chemokine Receptor Binding
Identical Protein Binding
Biological Process
Response To Hypoxia
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Heme Catabolic Process
Neutrophil Degranulation
Iron Ion Homeostasis
Blood Vessel Remodeling
Dendritic Cell Chemotaxis
Regulation Of T Cell Cytokine Production
Positive Regulation Of T-helper 1 Type Immune Response
Negative Regulation Of Type 2 Immune Response
Cellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Receptor Signaling Pathway Via JAK-STAT
Response To Wounding
Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of T Cell Chemotaxis
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Calcium-mediated Signaling
Cellular Homeostasis
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Monocyte Extravasation
T-helper 17 Cell Chemotaxis
Negative Regulation Of Eosinophil Degranulation
Regulation Of T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of T Cell Activation
Positive Regulation Of Synaptic Transmission, Glutamatergic
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages
Inflammatory Response To Wounding
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of NMDA Glutamate Receptor Activity
Macrophage Migration
Positive Regulation Of Thymocyte Migration
Positive Regulation Of Monocyte Extravasation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation
Positive Regulation Of Astrocyte Chemotaxis
Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways
Heme degradation
Neutrophil degranulation
Iron uptake and transport
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
NADH
Stannsoporfin
INCB3284
CCX915
Plozalizumab
Diseases
GWAS
Erectile dysfunction (
30583798
)
Blood protein levels (
28240269
23696881
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
29403010
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Obesity-related traits (
23251661
)
Rheumatoid arthritis (
32868391
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
67 interacting genes:
A2M
APP
AQP6
ARL13B
ASGR2
ATP5F1B
BCL2L13
BLOC1S2
CCR2
CD79A
CEBPZ
CEP126
COPS6
CRB3
CSNK2A1
EBP
EEF1G
EIF3C
ELOVL4
ELOVL5
ERGIC3
F2RL1
FAM209A
FAM210B
GET1
GIT1
GPR152
GPRASP1
GPX8
HAP1
IMMT
INPP5K
ITFG1
JADE1
KCNJ6
KCNMA1
LAPTM5
LMNA
LRIF1
MED31
MGST3
MTNR1A
NDUFS2
NKRF
NR3C1
PLXNB2
PTGER4
RBBP4
RETREG3
RNASEK
SAR1A
SETDB1
SGPL1
SHC1
SKA2
SLC30A8
SMO
SNX5
SNX7
SSMEM1
STOM
SYT1
TMEM14B
TMX2
VMA21
ZFP28
ZNF746
40 interacting genes:
APP
ARL6IP5
ATP2B1
B3GAT3
BLOC1S6
CACYBP
CD59
CD81
CDIP1
CLPTM1
DMWD
EMC10
ERGIC3
GOT1
GPR161
HERPUD1
HMOX2
JPH3
NDFIP1
NOTCH2
NTNG2
PCMT1
PLLP
PTPN9
RGR
RHOG
RTN3
S1PR5
SCG5
SLC2A1
SLC41A3
SRSF5
SUMO1
SVOP
TECPR2
TMEM161A
TMEM199
TMEM63A
TSPAN7
WLS
Entrez ID
3163
729230
HPRD ID
00783
19667
Ensembl ID
ENSG00000103415
ENSG00000121807
Uniprot IDs
A0A087WT44
B3KSE0
P30519
A0A024R2Q0
P41597
PDB IDs
2Q32
2QPP
2RGZ
4WMH
5UC8
5UC9
5UCA
1KAD
1KP1
2MLO
2MLQ
5T1A
Enriched GO Terms of Interacting Partners
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