HHEX and KRTAP4-12

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HHEX	KRTAP4-12
Description		hematopoietically expressed homeobox	keratin associated protein 4-12
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-DNA Complex	Keratin Filament
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Repressing Transcription Factor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases		Type II diabetes mellitus
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Circulating leptin levels or type 2 diabetes ( 32341051) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 31604244 24076602 21833088) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 22885922 18372903 24509480 17293876 30054458 22693455 20862305 29358691 30297969 26818947 23945395 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590)
Interacting Genes		40 interacting genes: ABI1 ABI2 APOBEC3C CYSRT1 EFEMP2 GATA2 GATA6 JUN KHDRBS2 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP19-1 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 MDFI NBPF19 NOTCH2NLA PFDN5 PML PSMA3 PSTPIP1 RBMY1F RBMY1J SOX10 SOX8 TLE1 TLE5 TP53BP2 TRMT6	152 interacting genes: ADAM12 ADAMTSL4 ALPP AQP1 ATG12 ATN1 AXIN1 BAG4 BAHD1 BEX2 C10orf62 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CDX2 CHCHD3 CHIC2 CHRD CLCNKA CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 CYSRT1 DBF4B DLK2 EIF4E2 ELOA2 FAM107A FAM27E3 FAM76B FBXL18 FBXO34 FBXW5 FCHO1 FUCA2 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 IGSF8 ILF3 KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP19-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP5-1 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NLA NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP POU4F2 PRKAB2 PRKAG1 PRR13 PTPMT1 QPRT R3HDM2 RERE RPS28 SHFL SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY1 SPRY2 TAP1 TBC1D16 TBC1D23 TGM1 THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF414 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF497 ZNF581 ZNF638 ZNF655 ZNF696 ZNF764 ZNF837 ZSCAN26
Entrez ID		3087	83755
HPRD ID		06829	13941
Ensembl ID		ENSG00000152804	ENSG00000213416
Uniprot IDs		Q03014	Q9BQ66
PDB IDs		2E1O
Enriched GO Terms of Interacting Partners?
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