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HHEX and KRTAP10-6
Data Source:
BioGRID
(two hybrid)
HHEX
KRTAP10-6
Description
hematopoietically expressed homeobox
keratin associated protein 10-6
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Protein-DNA Complex
Cytosol
Keratin Filament
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Transcription Factor Binding
Eukaryotic Initiation Factor 4E Binding
DNA Binding, Bending
TBP-class Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Repressing Transcription Factor Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
MRNA Export From Nucleus
Response To Wounding
Anterior/posterior Pattern Specification
Negative Regulation Of Transcription By Transcription Factor Localization
Negative Regulation Of Transcription By Competitive Promoter Binding
Wnt Signaling Pathway
Negative Regulation Of Angiogenesis
Poly(A)+ MRNA Export From Nucleus
Cell Differentiation
Positive Regulation Of Wnt Signaling Pathway
B Cell Differentiation
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Protein Localization To Nucleus
Response To Peptide Hormone
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Leukocyte Proliferation
DNA Conformation Change
Positive Regulation Of Canonical Wnt Signaling Pathway
Keratinization
Pathways
Keratinization
Drugs
Diseases
Type II diabetes mellitus
GWAS
Age-related cognitive decline (attention/processing speed) (slope of z-scores) (
30954325
)
Asthma (
31619474
)
Birth weight (
31043758
27680694
)
Body mass index (
28892062
)
Circulating leptin levels or type 2 diabetes (
32341051
)
Corrected insulin response (
24699409
)
Corrected insulin response adjusted for insulin sensitivity index (
24699409
)
Dehydroepiandrosterone sulphate levels (
21533175
)
Eosinophil counts (
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Hemoglobin A1c levels (
29403010
)
Inflammatory bowel disease (
28067908
)
Insulin disposition index (
24699409
)
Insulin levels in response to oral glucose tolerance test (30 minutes) (
29093273
)
Intraocular pressure (
29785010
)
Multiple sclerosis (
31604244
24076602
21833088
)
Sum eosinophil basophil counts (
27863252
)
Systolic blood pressure (
30224653
)
Type 2 diabetes (
22885922
18372903
24509480
17293876
30054458
22693455
20862305
29358691
30297969
26818947
23945395
32499647
20581827
19401414
17463246
30718926
17463248
17463249
28869590
)
Interacting Genes
40 interacting genes:
ABI1
ABI2
APOBEC3C
CYSRT1
EFEMP2
GATA2
GATA6
JUN
KHDRBS2
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP19-1
KRTAP2-3
KRTAP2-4
KRTAP4-12
KRTAP5-7
KRTAP5-8
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
MDFI
NBPF19
NOTCH2NLA
PFDN5
PML
PSMA3
PSTPIP1
RBMY1F
RBMY1J
SOX10
SOX8
TLE1
TLE5
TP53BP2
TRMT6
73 interacting genes:
ADAMTSL3
AVPI1
CLK1
CLK4
DHX57
DKK2
FOXD4
HAND1
HHEX
HOXB5
KIAA0040
KIF9
KRTAP10-5
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-2
KRTAP5-9
LCE1E
LCE1F
LCE2C
LCE2D
LCE3B
LCE3E
LCE4A
MFSD3
MOBP
MT1B
NAA10
NAXD
NKD1
NMU
NOL12
NPDC1
PBXIP1
PIN1
RSPO2
SNIP1
SPATA3
STRA6
VASN
WT1
YTHDC1
ZBTB24
ZC3HAV1
ZIM2
ZNF114
ZNF138
ZNF155
ZNF169
ZNF221
ZNF239
ZNF264
ZNF280C
ZNF302
ZNF319
ZNF418
ZNF440
ZNF479
ZNF490
ZNF543
ZNF563
ZNF595
ZNF600
ZNF669
ZNF672
ZNF679
ZNF696
ZNF774
ZNF776
ZNF792
ZNHIT1
Entrez ID
3087
386674
HPRD ID
06829
11192
Ensembl ID
ENSG00000152804
ENSG00000188155
Uniprot IDs
Q03014
P60371
PDB IDs
2E1O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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