HCFC1 and YY1

Data Source:
BioGRID (pull down)

		HCFC1	YY1
Description		host cell factor C1	YY1 transcription factor
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Membrane Protein-containing Complex Histone Methyltransferase Complex Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL1 Complex	Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Cytoplasm Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	Chromatin Binding Transcription Coactivator Activity Protein Binding Protein-macromolecule Adaptor Activity Activating Transcription Factor Binding Identical Protein Binding Cadherin Binding	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding RNA Binding Protein Binding SMAD Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Protein Deubiquitination Release From Viral Latency Regulation Of Protein-containing Complex Assembly Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Negative Regulation Of Gene Expression Protein Deubiquitination B Cell Differentiation Negative Regulation Of Interferon-beta Production Cellular Response To UV Response To Prostaglandin F Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Chromosome Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases	Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)	Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)
Interacting Genes		33 interacting genes: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 SUMO2 TAF9 THAP11 THAP7 YY1 ZBTB17	90 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BCCIP BRCA1 CDKN2A CEP76 CREB1 CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 GMCL1 GRN GTF2I HCFC1 HDAC2 HDAC3 HOXA11 IL10 INO80 KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MDFI MED20 MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PLEKHF2 PPIA PSMD9 RAF1 RUVBL1 RUVBL2 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UHRF2 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		3054	7528
HPRD ID		02061	02482
Ensembl ID		ENSG00000172534	ENSG00000100811
Uniprot IDs		A6NEM2 P51610	P25490
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5	1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?
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