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YY1 and GRN
Data Source:
BioGRID
(two hybrid)
YY1
GRN
Description
YY1 transcription factor
granulin precursor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin Silencing Complex
Cytoplasm
Nuclear Matrix
Ino80 Complex
PcG Protein Complex
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
Four-way Junction DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
SMAD Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
Regulation Of Transcription By RNA Polymerase II
RNA Localization
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Anterior/posterior Pattern Specification
Response To UV-C
Negative Regulation Of Gene Expression
Protein Deubiquitination
B Cell Differentiation
Negative Regulation Of Interferon-beta Production
Cellular Response To UV
Response To Prostaglandin F
Positive Regulation Of Transcription By RNA Polymerase II
Cell Development
Camera-type Eye Morphogenesis
Chromosome Organization
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Interleukin-1
Immunoglobulin Heavy Chain V-D-J Recombination
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
UCH proteinases
DNA Damage Recognition in GG-NER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Pulse pressure (
30224653
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
90 interacting genes:
ALOXE3
APP
ATF2
ATF6
ATF7
AURKA
BAP1
BCCIP
BRCA1
CDKN2A
CEP76
CREB1
CRKL
CYSRT1
DNMT3L
E2F2
E2F3
EED
EP300
ESM1
FHL2
FKBP1A
FKBP3
GMCL1
GRN
GTF2I
HCFC1
HDAC2
HDAC3
HOXA11
IL10
INO80
KAT2B
KRTAP1-3
KRTAP1-5
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP4-5
KRTAP5-6
KRTAP9-3
KRTAP9-8
LHX3
LHX4
MDFI
MED20
MTA2
MYC
NEDD4L
NFKB1
NOTCH1
NPM1
NR1H2
PLEKHF2
PPIA
PSMD9
RAF1
RUVBL1
RUVBL2
RYBP
SAP30
SF3A2
SKP2
SLC39A7
SMAD1
SMAD2
SMAD3
SMURF2
SP1
SPRY1
SREBF1
TESK1
TFCP2
TP53
TRIM42
TWIST1
UHRF2
VWC2
XAGE1A
XAGE1B
YAF2
ZNF232
ZNF85
ZRANB2
79 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
7528
2896
HPRD ID
02482
00733
Ensembl ID
ENSG00000100811
ENSG00000030582
Uniprot IDs
P25490
P28799
PDB IDs
1UBD
1ZNM
4C5I
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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