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HSPA1A and TOMM70
Data Source:
HPRD
(in vivo)
HSPA1A
TOMM70
Description
heat shock protein family A (Hsp70) member 1A
translocase of outer mitochondrial membrane 70
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Inclusion Body
Aggresome
Nuclear Speck
Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Outer Membrane Translocase Complex
Membrane
Integral Component Of Membrane
Extracellular Exosome
Molecular Function
Virus Receptor Activity
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
RNA Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Heat Shock Protein Binding
Denatured Protein Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Protein Folding Chaperone
Cadherin Binding
Protein N-terminus Binding
Unfolded Protein Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Disordered Domain Specific Binding
Protein Binding
Protein Transmembrane Transporter Activity
Mitochondrion Targeting Sequence Binding
Biological Process
MRNA Catabolic Process
Response To Unfolded Protein
Lysosomal Transport
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Vesicle-mediated Transport
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of RNA Splicing
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Unfolded Protein
Protein Refolding
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Positive Regulation Of Erythrocyte Differentiation
ATP Metabolic Process
Viral Entry Into Host Cell
Protein Stabilization
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Cell Death
Cellular Heat Acclimation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Positive Regulation Of Microtubule Nucleation
Negative Regulation Of Inclusion Body Assembly
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Cellular Response To Heat
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitotic Spindle Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoribonuclease Activity
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Protein Targeting To Mitochondrion
Macroautophagy
Protein Import Into Mitochondrial Matrix
Positive Regulation Of Interferon-beta Production
Regulation Of Apoptotic Process
Protein Insertion Into Mitochondrial Inner Membrane
Cellular Response To Virus
Pathways
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation
Mitochondrial protein import
PINK1-PRKN Mediated Mitophagy
Ub-specific processing proteases
Drugs
Diseases
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Inflammatory bowel disease (
28067908
)
Schizophrenia (
30285260
)
Ulcerative colitis (
28067908
)
Interacting Genes
88 interacting genes:
AIFM1
AIMP2
APAF1
APEX1
APOB
ATXN1
BAG1
BAG2
BAG3
BAG4
BCL2
BRSK1
CACNA1E
CDK9
CFAP52
DAPP1
DNAAF4
DNAJA2
DNAJA3
DNAJB1
DNAJB11
DNAJC3
EGFR
EIF2AK2
ERBB2
ERBB3
FANCC
FOS
GPR37
GRIN1
GRIN2D
HAP1
HCFC1
HEMGN
HIVEP1
HMGA1
HSBP1
HSF1
HSPA8
HSPBP1
IKBKG
INS
KRT18
KRT7
MAP3K5
MAPRE1
METTL21A
MOS
MSR1
NQO1
NR3C1
PEX5
PGR
PLG
POT1
PPP1R15A
PRKCA
PSMC5
PTGES3
PTMA
PTPRF
RAP1A
RAPGEF2
RHOA
SAE1
SLC13A1
SLC5A1
SNCB
SNRK
SOX9
ST13
STIP1
STUB1
SUMO2
TCERG1
TGM2
TOMM70
TP53
TRIAP1
TRIM24
TRIM38
TSSK6
TTC1
XIAP
YWHAB
YWHAG
YWHAQ
YWHAZ
7 interacting genes:
HSP90AA1
HSPA1A
HSPA1B
HSPB1
IRF3
PRKN
SNAPIN
Entrez ID
3303
9868
HPRD ID
00774
16194
Ensembl ID
ENSG00000204389
ENSG00000154174
Uniprot IDs
A8K5I0
B3KTT5
P0DMV8
P0DMV9
O94826
PDB IDs
1HJO
1S3X
1XQS
2E88
2E8A
2LMG
3A8Y
3ATU
3ATV
3AY9
3D2E
3D2F
3JXU
3LOF
3Q49
4IO8
4J8F
4PO2
4WV5
4WV7
5AQW
5AQX
5AQY
5AQZ
5AR0
5BN8
5BN9
5BPL
5BPM
5BPN
5GJJ
5MKR
5MKS
5XI9
5XIR
6FDT
6FHK
6G3R
6G3S
6JPV
6K39
7KDT
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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