GRK6 and FSHR

Data Source:
HPRD (in vitro)

		GRK6	FSHR
Description		G protein-coupled receptor kinase 6	follicle stimulating hormone receptor
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		G alpha (s) signalling events	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases			Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Ovarian hyperstimulation syndrome (OHSS)
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	20 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		2870	2492
HPRD ID		02925	00639
Ensembl ID		ENSG00000198055	ENSG00000170820
Uniprot IDs		B3KPS5 P43250	A0A1D5RMN4 P23945
PDB IDs		2ACX 3NYN 3NYO	1XUN 1XWD 4AY9 4MQW
Enriched GO Terms of Interacting Partners?
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