GP1BA and TPST1

Data Source:
HPRD (in vivo)

		GP1BA	TPST1
Description		glycoprotein Ib platelet subunit alpha	tyrosylprotein sulfotransferase 1
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Anchored Component Of External Side Of Plasma Membrane Extracellular Exosome	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding Thrombin-activated Receptor Activity	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Regulation Of Megakaryocyte Differentiation Thrombin-activated Receptor Signaling Pathway Platelet Aggregation	Peptidyl-tyrosine Sulfation Inflammatory Response Protein Phosphopantetheinylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation	Cytosolic sulfonation of small molecules Gamma carboxylation, hypusine formation and arylsulfatase activation Defective F8 sulfation at Y1699
Drugs		Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Blood protein levels ( 30072576 29875488) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 29403010 32888494 20139978 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Blood protein levels ( 30072576 29875488) Gout ( 22179738)
Interacting Genes		17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ	6 interacting genes: CCR1 CCR8 CMKLR1 GP1BA GPR1 SELPLG
Entrez ID		2811	8460
HPRD ID		01976	07216
Ensembl ID		ENSG00000185245	ENSG00000169902
Uniprot IDs		L7UYB8 P07359	A0A024RDK9 O60507
PDB IDs		1GWB 1K13 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6	5WRI 5WRJ
Enriched GO Terms of Interacting Partners?
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