GOT1 and TMEM120A

Data Source:
HPRD (two hybrid)

		GOT1	TMEM120A
Description		glutamic-oxaloacetic transaminase 1	transmembrane protein 120A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome	Cellular_component Nuclear Inner Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity	Molecular_function Ion Channel Activity Protein Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Cellular Amino Acid Biosynthetic Process Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle	Ion Transmembrane Transport Fat Cell Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Protein Homooligomerization Protein Heterooligomerization
Pathways		Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism
Drugs		Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic Acid Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010) Thyroid stimulating hormone levels ( 32769997)	Coffee consumption ( 25288136) Coffee consumption (cups per day) ( 25288136)
Interacting Genes		6 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC TMEM120A	24 interacting genes: AQP6 CYBRD1 FAM209A FBXO7 GOT1 GPRC5B HSD17B13 LEPROT LRRC25 ORMDL2 PAXIP1 PPP1CC PTAFR SCN3B STX1A STX2 TMEM14B TMEM35A TMEM86B TMX2 TPRG1 TSPAN18 UBC VKORC1
Entrez ID		2805	83862
HPRD ID		00687	15543
Ensembl ID		ENSG00000120053	ENSG00000189077
Uniprot IDs		A0A140VK69 P17174	A0A087X266 Q9BXJ8
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND
Enriched GO Terms of Interacting Partners?
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