Wiki-Pi
About
Search
Browse
People
Updates
Search
GOT1 and AGTR1
Data Source:
BioGRID
(two hybrid)
GOT1
AGTR1
Description
glutamic-oxaloacetic transaminase 1
angiotensin II receptor type 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Axon Terminus
Extracellular Exosome
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Molecular Function
L-aspartate:2-oxoglutarate Aminotransferase Activity
Phosphatidylserine Decarboxylase Activity
Pyridoxal Phosphate Binding
Carboxylic Acid Binding
L-cysteine:2-oxoglutarate Aminotransferase Activity
Angiotensin Type I Receptor Activity
G Protein-coupled Receptor Activity
Angiotensin Type II Receptor Activity
Protein Binding
Bradykinin Receptor Binding
Protein Heterodimerization Activity
Biological Process
Gluconeogenesis
2-oxoglutarate Metabolic Process
Oxaloacetate Metabolic Process
Glycerol Biosynthetic Process
Aspartate Metabolic Process
Aspartate Biosynthetic Process
Aspartate Catabolic Process
Glutamate Metabolic Process
Notch Signaling Pathway
Cellular Amino Acid Biosynthetic Process
Response To Carbohydrate
Glutamate Catabolic Process To Aspartate
Glutamate Catabolic Process To 2-oxoglutarate
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Negative Regulation Of Collagen Biosynthetic Process
Response To Immobilization Stress
Response To Cadmium Ion
Response To Glucocorticoid
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Mitochondrial Depolarization
Fatty Acid Homeostasis
Transdifferentiation
Cellular Response To Mechanical Stimulus
Response To Transition Metal Nanoparticle
Regulation Of Cell Growth
Kidney Development
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Rho Protein Signal Transduction
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Esterification
Regulation Of Vasoconstriction
Calcium-mediated Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Phospholipase A2 Activity
Positive Regulation Of NAD(P)H Oxidase Activity
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Cell Chemotaxis
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Blood Vessel Diameter Maintenance
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Methionine salvage pathway
Gluconeogenesis
Aspartate and asparagine metabolism
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Pyridoxal phosphate
Aspartic acid
Glutamic acid
Cysteine
Adapalene
Maleic Acid
Copper
Valsartan
Olmesartan
Losartan
Candesartan cilexetil
Eprosartan
Telmisartan
Irbesartan
Forasartan
Saprisartan
Tasosartan
CYT006-AngQb
Azilsartan medoxomil
Fimasartan
Angiotensin II
Candesartan
Diseases
Renal tubular dysgenesis
GWAS
Aspartate aminotransferase levels (
30718733
21900944
)
Crohn's disease (
22412388
)
Hypothyroidism (
27182965
)
Liver enzyme levels (aspartate transaminase) (
24124411
)
Mean corpuscular volume (
29403010
)
Thyroid stimulating hormone levels (
32769997
)
Birth weight (
31043758
)
Chin dimples (
27182965
)
Height (
31562340
)
Lead levels in blood (
25820613
)
Monobrow (
27182965
)
Type 2 diabetes (
31049640
)
Interacting Genes
6 interacting genes:
ABI3BP
AGTR1
CCR2
EGFR
PC
TMEM120A
76 interacting genes:
ABI3
ADD3
AGT
AGTRAP
AP2M1
ARFGAP1
ARHGDIG
ARRB1
ARRB2
ATP13A1
ATP1B1
BAALC
BASP1
BDKRB2
BNIP3
BRD8
CBR1
CCDC25
CD37
CERS6
CUEDC2
DBNDD2
DNAJC14
DNAJC8
EGFR
FAM13B
FBXW11
FNBP1
GHITM
GNA12
GOT1
GPAA1
GPRASP1
GRK2
GRK3
GRK5
HDGFL2
HHATL
HRAS
JAK1
JAK2
JKAMP
KIAA0930
LCNL1
LLGL1
LZTS1
NACAD
NDRG2
NOS3
NPTN
NUP88
OAZ1
PCMT1
PDE6H
PLCG1
PLCH2
PNMA1
PPP1R3F
PSMD10
PTGFR
RAB5A
RAF1
RBSN
RTN3
SAE1
SCG5
SELENOF
SERINC3
SLC16A1
SPG21
THOP1
TMEM161A
TMEM80
UBR4
UGT8
YWHAQ
Entrez ID
2805
185
HPRD ID
00687
00107
Ensembl ID
ENSG00000120053
ENSG00000144891
Uniprot IDs
A0A140VK69
P17174
A0A0A0MSE3
D3DNG8
P30556
Q53YY0
Q6NUP5
PDB IDs
3II0
3WZF
6DNA
6DNB
6DND
1ZV0
4YAY
4ZUD
6DO1
6OS0
6OS1
6OS2
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?