RPS6KA6 and NR4A1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS6KA6	NR4A1
Description		ribosomal protein S6 kinase A6	nuclear receptor subfamily 4 group A member 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrion Cytosol Nuclear Membrane
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Glucocorticoid Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Intracellular Receptor Signaling Pathway Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Fat Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	87 interacting genes: ABCA5 ABCB11 ABCC13 ABCC6 ABCG8 AKT1 ANKIB1 ARHGEF10L ARHGEF5 ATM ATXN1 BBS10 BCL2 BCL2A1 BCL2L10 CD2AP CDKN2D CHD1L CHD3 CHEK2 CPT1A CUTA DIABLO EP300 FAF1 FXYD3 GADD45GIP1 GK GLOD4 GLUD1 HADHA HES1 HIF1A HNRNPA2B1 HSP90AB1 KAT2B KRTAP10-1 KRTAP10-5 LONRF1 LSS MAP3K1 MAPK1 MAPK8 MED1 MED31 NACAD NCOA1 NCOA2 NCOA3 NCOR2 NDRG1 NFKB1 NR3C1 PGBD1 PML POLA2 PPARG PPBP PPM1A PRDX4 PRDX6 RBL1 ROBO2 RPL7 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KA6 RTN4 RXRA RXRG SERPINA4 SERPING1 SMAD3 SOCS4 STAT3 SUGT1 TCF4 TP53 TRAF2 TRIM28 TUBB4A VASP VHL YWHAZ ZNF331 ZNF579
Entrez ID		27330	3164
HPRD ID		02250	00744
Ensembl ID		ENSG00000072133	ENSG00000123358
Uniprot IDs		Q9UK32	A0A024R126 F5GXF0 P22736 Q6ZMM6
PDB IDs		6G76 6G77 6G78	2QW4 3V3E 3V3Q 4JGV 4KZI 4KZJ 4KZM 4RE8 4REE 4REF 4RZE 4RZF 4RZG 4WHF 4WHG 6KZ5 6LC1
Enriched GO Terms of Interacting Partners?
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