GJB1 and TMEM14C

Data Source:
BioGRID (two hybrid)

		GJB1	TMEM14C
Description		gap junction protein beta 1	transmembrane protein 14C
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane	Mitochondrial Inner Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding
	Biological Process	Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	Heme Biosynthetic Process Mitochondrial Transport Erythrocyte Differentiation Regulation Of Heme Biosynthetic Process
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Itch intensity from mosquito bite adjusted by bite size ( 28199695) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	45 interacting genes: ARL13B BCL2L13 BIK CLDN5 COMT COQ9 CPLANE2 CREB3 CREB3L1 CYB5R3 EBP ELOVL7 FAM209A GJB1 GORAB GPR152 HSD17B13 KASH5 LMNA LNX1 MARCHF8 MFF MMGT1 MTERF3 MUC1 NCAPH2 NCR3LG1 PDZK1IP1 PLIN3 RCHY1 SDC3 SLC10A6 SSMEM1 STX1A SYT1 TMEM14B TMEM31 TMEM35A TMEM52B TMEM79 TMEM86B TMX2 VSIR ZDHHC15 ZFYVE27
Entrez ID		2705	51522
HPRD ID		02367	15524
Ensembl ID		ENSG00000169562	ENSG00000111843
Uniprot IDs		A0A654ICJ7 P08034	A0A024R001 Q9P0S9
PDB IDs		1TXH 5KK9	2LOS
Enriched GO Terms of Interacting Partners?
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