NPTN and AGTR1

Data Source:
BioGRID (two hybrid)

		NPTN	AGTR1
Description		neuroplastin	angiotensin II receptor type 1
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GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Cell Surface Axon Dendrite Presynaptic Membrane Inhibitory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Protein Binding Ion Channel Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cellular Calcium Ion Homeostasis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Positive Regulation Of Neuron Projection Development Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Dendrite Self-avoidance Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Receptor Localization To Synapse Positive Regulation Of Cellular Protein Localization Excitatory Synapse Assembly	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		GABA receptor activation	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Tourette syndrome ( 30818990) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		3 interacting genes: AGTR1 SURF2 UBC	76 interacting genes: ABI3 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		27020	185
HPRD ID		18033	00107
Ensembl ID		ENSG00000156642	ENSG00000144891
Uniprot IDs		Q9Y639	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		6A69	1ZV0 4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?
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