GIGYF2 and CNOT9

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, pull down)

		GIGYF2	CNOT9
Description		GRB10 interacting GYF protein 2	CCR4-NOT transcription complex subunit 9
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Protein-containing Complex Perikaryon Proximal Dendrite	P-body Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Proline-rich Region Binding	Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity Protein Homodimerization Activity
	Biological Process	Posttranscriptional Gene Silencing Negative Regulation Of Translation Insulin-like Growth Factor Receptor Signaling Pathway MRNA Destabilization	Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Gene Silencing By RNA Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways			Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Anxiety and stress-related disorders ( 31116379) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		8 interacting genes: APC CNOT9 GRB10 GRB14 GRB7 RBM12 SNRPB WBP11	10 interacting genes: AKT1 EGFR GADD45A GADD45B GADD45G GIGYF1 GIGYF2 GRB10 MESD MYB
Entrez ID		26058	9125
HPRD ID		11639	08828
Ensembl ID		ENSG00000204120	ENSG00000144580
Uniprot IDs		Q6Y7W6	D5MQE1 Q92600
PDB IDs		5NVL 5NVM	2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON
Enriched GO Terms of Interacting Partners?
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