NCR3 and CD59

Data Source:
HPRD (in vivo, in vitro)

		NCR3	CD59
Description		natural cytotoxicity triggering receptor 3	CD59 molecule (CD59 blood group)
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Anchored Component Of External Side Of Plasma Membrane Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Complement Binding Protein Binding
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Negative Regulation Of Activation Of Membrane Attack Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Blood Coagulation Regulation Of Complement Activation Neutrophil Degranulation COPII Vesicle Coating Regulation Of Complement-dependent Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	COPII-mediated vesicle transport Cargo concentration in the ER Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Weight ( 19079260)	Blood protein levels ( 30072576 29875488) Body size at age 10 ( 32376654) Chronotype ( 30696823) Fruit consumption ( 32066663) Morning person ( 30696823)
Interacting Genes		5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G	16 interacting genes: C8A C9 CCR2 CD2 CD8A CD9 CHRM4 EGFR FAM209A GNAI3 NCR1 NCR3 SLC13A1 SLC6A8 SMAD4 SRC
Entrez ID		259197	966
HPRD ID		11384	00117
Ensembl ID		ENSG00000204475	ENSG00000085063
Uniprot IDs		O14931 Q05D23	P13987 Q6FHM9
PDB IDs		3NOI 3PV6 6YJP	1CDQ 1CDR 1CDS 1ERG 1ERH 2J8B 2OFS 2UWR 2UX2 4BIK 5IMT 5IMY
Enriched GO Terms of Interacting Partners?
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