ARIH1 and SEC31A

Data Source:
BioGRID (enzymatic study)

		ARIH1	SEC31A
Description		ariadne RBR E3 ubiquitin protein ligase 1	SEC31 homolog A, COPII coat complex component
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II IRE1-mediated Unfolded Protein Response COPII Vesicle Coating Response To Calcium Ion COPII-coated Vesicle Cargo Loading
Pathways		ISG15 antiviral mechanism	COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS			Adult asthma ( 27611488) Neutrophil percentage of white cells ( 27863252)
Interacting Genes		17 interacting genes: CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PLD1 RBX1 SEC31A UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2	14 interacting genes: APC ARIH1 FHL5 KLHL12 MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC22D2 USP8
Entrez ID		25820	22872
HPRD ID		05730	15314
Ensembl ID		ENSG00000166233	ENSG00000138674
Uniprot IDs		Q9Y4X5	A0A024RDH6 A1LU61 O94979
PDB IDs		1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH	3WXA
Enriched GO Terms of Interacting Partners?
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