RAD54B and SFRP2

Data Source:
BioGRID (two hybrid)

		RAD54B	SFRP2
Description		RAD54 homolog B	secreted frizzled related protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	DNA Binding DNA Helicase Activity RNA Helicase Activity Protein Binding ATP Binding DNA Translocase Activity	Fibronectin Binding Integrin Binding Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Mitotic Recombination Reciprocal Meiotic Recombination Determination Of Adult Lifespan Response To Ionizing Radiation DNA Duplex Unwinding Response To Drug	Branching Involved In Blood Vessel Morphogenesis Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Cellular Response To Extracellular Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Response To Drug Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Bone Morphogenesis Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Nonsyndromic cleft lip with cleft palate ( 28232668)	Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		30 interacting genes: ANKRD36BP1 ATPAF2 BAAT CCDC33 CDC23 CSNK1E DMC1 DYRK2 ELOA ENKD1 GMCL1 GORASP2 IGFBP3 LNX1 MDM4 MYO15B NIF3L1 NUDT18 PRKAA1 PSMA1 RAD51 RIBC2 SFRP2 SUMO1 TCEANC TRAPPC6A TRMO UBE2I WRN ZNF580	15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4
Entrez ID		25788	6423
HPRD ID		05049	16041
Ensembl ID		ENSG00000197275	ENSG00000145423
Uniprot IDs		O95073 Q9Y620	A0A140VJU3 B3KSM5 Q96HF1
PDB IDs
Enriched GO Terms of Interacting Partners?
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