SFRP2 and SFRP5

Data Source:
BioGRID (two hybrid)

		SFRP2	SFRP5
Description		secreted frizzled related protein 2	secreted frizzled related protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Collagen-containing Extracellular Matrix	Extracellular Space
	Molecular Function	Fibronectin Binding Integrin Binding Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity	Wnt-protein Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Cellular Response To Extracellular Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Response To Drug Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Bone Morphogenesis Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation	Apoptotic Process Establishment Or Maintenance Of Cell Polarity Signal Transduction Multicellular Organism Development Visual Perception Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Involved In Digestive Tract Morphogenesis
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)	Blood pressure ( 24954895) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4	1 interacting genes: SFRP2
Entrez ID		6423	6425
HPRD ID		16041	09166
Ensembl ID		ENSG00000145423	ENSG00000120057
Uniprot IDs		A0A140VJU3 B3KSM5 Q96HF1	Q5T4F7
PDB IDs
Enriched GO Terms of Interacting Partners?
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