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NR5A1 and SMARCD3
Data Source:
HPRD
(in vitro)
NR5A1
SMARCD3
Description
nuclear receptor subfamily 5 group A member 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
SWI/SNF Complex
NpBAF Complex
NBAF Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Nuclear Receptor Activity
Protein Binding
Phospholipid Binding
Zinc Ion Binding
Enzyme Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Transcription Coactivator Activity
Signaling Receptor Binding
Transcription Factor Binding
Nuclear Hormone Receptor Binding
Biological Process
Luteinization
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Sex Determination
Primary Sex Determination
Male Gonad Development
Female Gonad Development
Hormone-mediated Signaling Pathway
Tissue Development
Multicellular Organism Aging
Positive Regulation Of Gene Expression
Cell Differentiation
Male Sex Determination
Adrenal Gland Development
Intracellular Receptor Signaling Pathway
Hormone Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Steroid Biosynthetic Process
Maintenance Of Protein Location In Nucleus
Response To Gonadotropin-releasing Hormone
Calcineurin-mediated Signaling
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Neuroblast Proliferation
Secondary Heart Field Specification
Cardiac Right Ventricle Formation
Neural Retina Development
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Lipid Metabolic Process
Muscle Cell Differentiation
Regulation Of Protein Binding
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Smooth Muscle Cell Differentiation
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation of testis differentiation
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Circadian Clock
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE
Phosphatidyl ethanol
Diseases
Premature ovarian failure
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Chronotype (
30696823
)
Eyebrow thickness (
26926045
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
IgG glycosylation (
23382691
)
Immunoglobulin light chain (AL) amyloidosis (
28025584
)
Multiple myeloma (
27363682
)
Red blood cell count (
32888494
)
Interacting Genes
35 interacting genes:
AR
C2CD6
CKS1B
CREBBP
CTNNB1
CXXC1
EDF1
GATA4
GTF2B
JUN
MAPK1
NCK2
NCOA1
NFKB2
NFYA
NR0B1
NRIP1
NTAQ1
PIAS1
PITX1
PNRC2
PROX1
RAD54L2
RFC5
SMARCD3
SOX2
SOX8
SOX9
SP1
TBX19
TEKT4
TRAPPC2
TRERF1
UBE2I
ZNF653
20 interacting genes:
ARHGAP1
CCNE1
ESR1
ESRRA
FANCA
JUN
MAPK14
NR1H4
NR5A1
NR5A2
PBX1
PPARG
RARA
RARB
RARG
RORA
RXRA
SMARCC1
SREBF1
STARD13
Entrez ID
2516
6604
HPRD ID
01702
03440
Ensembl ID
ENSG00000136931
ENSG00000082014
Uniprot IDs
F1D8R8
Q13285
A0A090N8Z9
Q6STE5
PDB IDs
1YOW
1ZDT
4QJR
4QK4
Enriched GO Terms of Interacting Partners
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