NR5A1 and ZNF653

Data Source:
HPRD (in vitro, in vivo)

		NR5A1	ZNF653
Description		nuclear receptor subfamily 5 group A member 1	zinc finger protein 653
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Extracellular Region Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Metal Ion Binding AF-2 Domain Binding
	Biological Process	Luteinization Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		35 interacting genes: AR C2CD6 CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	7 interacting genes: CEP76 LONRF1 MAPRE1 NR5A1 TRIM41 TRIM55 TRIM63
Entrez ID		2516	115950
HPRD ID		01702	15889
Ensembl ID		ENSG00000136931	ENSG00000161914
Uniprot IDs		F1D8R8 Q13285	Q96CK0
PDB IDs		1YOW 1ZDT 4QJR 4QK4
Enriched GO Terms of Interacting Partners?
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