RNASEH1 and NCS1

Data Source:
BioGRID (two hybrid)

		RNASEH1	NCS1
Description		ribonuclease H1	neuronal calcium sensor 1
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GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Magnesium Ion Binding Nucleic Acid Binding RNA Binding RNA-DNA Hybrid Ribonuclease Activity Ribonuclease Activity Protein Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	RNA Catabolic Process DNA Replication, Removal Of RNA Primer RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		8 interacting genes: ASPH EMD FAM3C NCS1 NRM TM9SF1 TMEM11 TRIM63	27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		246243	23413
HPRD ID		04989	04500
Ensembl ID		ENSG00000171865	ENSG00000107130
Uniprot IDs		B3KUD4 E5KN15 O60930	A0A024R8B2 P62166
PDB IDs		2QK9 2QKB 2QKK 3BSU	1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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