NCS1 and IL1RAPL1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NCS1	IL1RAPL1
Description		neuronal calcium sensor 1	interleukin 1 receptor accessory protein like 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Axon Dendrite Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	Signaling Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Exocytosis Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Cellular Response To Cytokine Stimulus Presynaptic Membrane Assembly Regulation Of Postsynapse Organization Trans-synaptic Signaling By Trans-synaptic Complex Regulation Of Presynapse Assembly
Pathways			Receptor-type tyrosine-protein phosphatases Interleukin-38 signaling
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Non-syndromic X-linked mental retardation
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)	Cardiovascular risk factors (age interaction) ( 20838585) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Vitiligo ( 27723757)
Interacting Genes		27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10	2 interacting genes: ARHGAP22 NCS1
Entrez ID		23413	11141
HPRD ID		04500	02193
Ensembl ID		ENSG00000107130	ENSG00000169306
Uniprot IDs		A0A024R8B2 P62166	Q9NZN1 X5DNQ7
PDB IDs		1G8I 2LCP 4GUK 5O9S 6QI4	1T3G 4M92 5WY8
Enriched GO Terms of Interacting Partners?
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