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FKBP8 and SMO
Data Source:
BioGRID
(two hybrid)
FKBP8
SMO
Description
FKBP prolyl isomerase 8
smoothened, frizzled class receptor
Image
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Mitochondrial Membrane
Protein-containing Complex
Golgi Apparatus
Plasma Membrane
Caveola
Cilium
Integral Component Of Membrane
Dendrite
Endocytic Vesicle Membrane
Intracellular Membrane-bounded Organelle
Ciliary Membrane
Extracellular Exosome
Ciliary Tip
9+0 Non-motile Cilium
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
Identical Protein Binding
Protein Folding Chaperone
Metal Ion Binding
Disordered Domain Specific Binding
G Protein-coupled Receptor Activity
Patched Binding
Protein Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Cell Fate Specification
Negative Regulation Of Protein Phosphorylation
Protein Folding
Apoptotic Process
Smoothened Signaling Pathway
Regulation Of Gene Expression
Viral Process
Dorsal/ventral Neural Tube Patterning
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intracellular Signal Transduction
Camera-type Eye Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Osteoblast Differentiation
In Utero Embryonic Development
Cell Fate Specification
Neural Crest Cell Migration
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Determination Of Left/right Asymmetry In Lateral Mesoderm
Type B Pancreatic Cell Development
G Protein-coupled Receptor Signaling Pathway
Smoothened Signaling Pathway
Positive Regulation Of Hh Target Transcription Factor Activity
Ventral Midline Determination
Central Nervous System Development
Midgut Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Thalamus Development
Dorsal/ventral Neural Tube Patterning
Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation
Central Nervous System Neuron Differentiation
Cerebral Cortex Development
Positive Regulation Of Cell Migration
Negative Regulation Of Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Protein Localization To Nucleus
Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Positive Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Astrocyte Activation
Skeletal Muscle Fiber Development
Smooth Muscle Tissue Development
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Epithelial Cell Proliferation
Protein Stabilization
Myoblast Migration
Negative Regulation Of Hair Follicle Development
Contact Inhibition
Atrial Septum Morphogenesis
Mammary Gland Epithelial Cell Differentiation
Epithelial-mesenchymal Cell Signaling
Somite Development
Pancreas Morphogenesis
Left/right Axis Specification
Cellular Response To Cholesterol
Commissural Neuron Axon Guidance
Mesenchymal To Epithelial Transition Involved In Metanephric Renal Vesicle Formation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Stem Cell Population Maintenance
Regulation Of Heart Morphogenesis
Pathways
Ub-specific processing proteases
Class B/2 (Secretin family receptors)
Hedgehog 'off' state
BBSome-mediated cargo-targeting to cilium
Hedgehog 'on' state
Activation of SMO
Activation of SMO
Drugs
Fluocinonide
Halcinonide
Vismodegib
Sonidegib
Glasdegib
Diseases
Basal cell carcinoma
GWAS
Plasma parathyroid hormone levels (
30134803
)
Urinary potassium excretion (
31409800
)
Osteoarthritis (hip) (
30374069
)
Interacting Genes
48 interacting genes:
ANKMY2
ARHGEF5
ARL13B
ATP13A2
BCL2
BCL2L1
BNIPL
CD79A
CIDEB
CLCN1
CXCR2
CYB561
CYBRD1
EBP
EGFR
ELOVL4
ERBB2
ERGIC3
FAM174A
FGF14
GPR37
JAGN1
MAPK14
MFSD14B
MTOR
PEX12
PLN
PPP3CA
PSMC1
PSMD2
RETREG3
RHBDD2
RHEB
SCN3B
SLC10A6
SLC35A5
SLC35B1
SMO
TERF1
TMEM14B
TMEM254
TMEM31
TMEM43
TMEM45B
TMEM80
TMX1
VHL
ZFPL1
28 interacting genes:
ARV1
C18orf32
C4orf3
EMC10
FKBP8
GABARAPL2
GABBR1
HMGN4
HMOX1
HMOX2
ITGB1BP1
JPH3
LEPROT
NDFIP1
NEDD4
NGEF
NIPA1
PLPP7
PTCH1
PTCH2
RPN2
S1PR5
SLC41A3
SSPN
TIMMDC1
TMCC2
TSPAN7
WLS
Entrez ID
23770
6608
HPRD ID
05327
03294
Ensembl ID
ENSG00000105701
ENSG00000128602
Uniprot IDs
A0A024R7P2
B2R8G6
Q14318
Q99835
PDB IDs
2AWG
2D9F
2F2D
2MF9
3EY6
5MGX
4JKV
4N4W
4O9R
4QIM
4QIN
5L7D
5L7I
5V56
5V57
6OT0
6XBJ
6XBK
6XBL
6XBM
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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