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NUP62 and AGR3
Data Source:
BioGRID
(two hybrid)
NUP62
AGR3
Description
nucleoporin 62
anterior gradient 3, protein disulphide isomerase family member
Image
GO Annotations
Cellular Component
Spindle Pole
Nuclear Envelope
Annulate Lamellae
Nuclear Pore
Nucleoplasm
Cytoplasm
Centrosome
Nuclear Membrane
Host Cell
Nuclear Pore Central Transport Channel
Mitotic Spindle
Flemming Body
Ribonucleoprotein Complex
Endoplasmic Reticulum
Intracellular Membrane-bounded Organelle
Molecular Function
Chromatin Binding
Protein Binding
Phospholipid Binding
Structural Constituent Of Nuclear Pore
Kinesin Binding
Signaling Receptor Complex Adaptor Activity
Hsp70 Protein Binding
SH2 Domain Binding
Ubiquitin Binding
Protein-containing Complex Binding
PTB Domain Binding
Hsp90 Protein Binding
Dystroglycan Binding
Protein Binding
Biological Process
Regulation Of Glycolytic Process
RNA Export From Nucleus
MRNA Export From Nucleus
TRNA Export From Nucleus
Protein Import Into Nucleus
Mitotic Metaphase Plate Congression
Centrosome Cycle
Mitotic Centrosome Separation
Cell Surface Receptor Signaling Pathway
Spermatogenesis
Cell Aging
Cell Death
Negative Regulation Of Cell Population Proliferation
Regulation Of Signal Transduction
Viral Process
Protein Sumoylation
Viral Transcription
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Ras Protein Signal Transduction
Positive Regulation Of Centriole Replication
Regulation Of Mitotic Spindle Organization
Regulation Of Gene Silencing By MiRNA
Intracellular Transport Of Virus
Centriole Assembly
Regulation Of Cellular Response To Heat
Positive Regulation Of Mitotic Cytokinetic Process
Positive Regulation Of Protein Localization To Centrosome
Biological_process
Negative Regulation Of Cell Death
Pathways
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS
Coffee consumption (
31959922
29367735
)
Cutaneous malignant melanoma (
32341527
26237428
)
Cutaneous squamous cell carcinoma (
32041948
)
Diffusing capacity of carbon monoxide (
30694715
)
Lung cancer in ever smokers (
28604730
)
Melanoma (
28212542
)
Refractive error (
32231278
)
Residual cognition (
28441426
)
Rosacea symptom severity (
29771307
)
Type 2 diabetes (dietary heme iron intake interaction) (
23386860
)
Urinary albumin excretion (
30220432
)
Urinary albumin excretion (no hypertensive medication) (
30220432
)
Interacting Genes
91 interacting genes:
ABI2
ADAM15
AGR3
ARFIP2
ATF7IP2
ATXN7
BFSP1
BLOC1S6
C14orf119
C1orf216
CAVIN3
CCDC121
CCDC146
CCDC150
CCDC153
CCHCR1
CENPU
CEP57L1
CLIC1
CRCT1
DDX3X
DGCR6
DPPA3
DTNB
DYNLT1
FABP3
GOPC
GORASP2
GTF2E2
HAUS1
HGS
HSF2
HSF4
HSPB11
IDH1
IFT20
IK
IKBIP
IPO5
ISCU
KANSL1
KIFC3
KLHL32
KPNA1
KPNA2
KPNB1
KRT1
KRT20
KRT3
KRT6A
KRT6B
KRT75
LMO2
LNX1
MUC1
MXD3
MYO15B
NFX1
NUP153
NUP214
NUP54
NUP58
NUP88
NUP98
NUTF2
NXF1
NXF2
OGT
OIP5
OTUD6A
PBX2
PELI2
PHF21A
PIN1
PTMA
RANBP2
SMARCE1
SNAPC5
SP1
SSC5D
SUOX
THAP1
TLE4
TRAF3
TRIML2
TXLNA
TXN
USHBP1
WASHC3
XPO1
XPO6
35 interacting genes:
AKT1
AP1B1
APC
ASB10
BCAR3
CASP8
CATSPER1
CD46
CGRRF1
CNNM3
DAG1
DESI1
EDA2R
ERLIN1
ESR2
FXYD3
KRTAP11-1
LIME1
LSM1
LYPD3
MMGT1
NRM
NTAQ1
NUP62
PDZK1IP1
PRAF2
PTPN1
SGTA
SGTB
SPINT1
TGFB1
TIMMDC1
TMEM14B
UBQLN1
UBQLN2
Entrez ID
23636
155465
HPRD ID
05782
16545
Ensembl ID
ENSG00000213024
ENSG00000173467
Uniprot IDs
A0A024QZF1
P37198
Q8TD06
PDB IDs
2H4D
5IJN
5IJO
3PH9
Enriched GO Terms of Interacting Partners
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