CARHSP1 and PIAS3

Data Source:
BioGRID (two hybrid)

		CARHSP1	PIAS3
Description		calcium regulated heat stable protein 1	protein inhibitor of activated STAT 3
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GO Annotations	Cellular Component	Cytoplasmic Exosome (RNase Complex) P-body Cytoplasm Cytosol P Granule	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse
	Molecular Function	MRNA 3'-UTR Binding Protein Binding Phosphatase Binding	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity
	Biological Process	Intracellular Signal Transduction Regulation Of MRNA Stability	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway
Pathways			SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Intracranial aneurysm ( 29531279)
Interacting Genes		26 interacting genes: AKAP8L AKT1 CDC42 CYSRT1 DOCK8 GORASP2 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP6-3 MID2 NBPF19 NOTCH2NLA PIAS3 PIN1 PNMA1 PPP2R1A RPS6KA1 SGK1 SMN1 SRPK2 STC2 STYX TK1 TRAF1 TSC22D1	55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2
Entrez ID		23589	10401
HPRD ID		08515	09068
Ensembl ID		ENSG00000153048	ENSG00000131788
Uniprot IDs		Q9Y2V2	B3KNI3 Q9Y6X2
PDB IDs		3AQQ	4MVT
Enriched GO Terms of Interacting Partners?
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