PIAS3 and CARHSP1

Data Source:
BioGRID (two hybrid)

		PIAS3	CARHSP1
Description		protein inhibitor of activated STAT 3	calcium regulated heat stable protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Cytoplasmic Exosome (RNase Complex) P-body Cytoplasm Cytosol P Granule
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	MRNA 3'-UTR Binding Protein Binding Phosphatase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Intracellular Signal Transduction Regulation Of MRNA Stability
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Intracranial aneurysm ( 29531279)
Interacting Genes		55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	26 interacting genes: AKAP8L AKT1 CDC42 CYSRT1 DOCK8 GORASP2 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP6-3 MID2 NBPF19 NOTCH2NLA PIAS3 PIN1 PNMA1 PPP2R1A RPS6KA1 SGK1 SMN1 SRPK2 STC2 STYX TK1 TRAF1 TSC22D1
Entrez ID		10401	23589
HPRD ID		09068	08515
Ensembl ID		ENSG00000131788	ENSG00000153048
Uniprot IDs		B3KNI3 Q9Y6X2	Q9Y2V2
PDB IDs		4MVT	3AQQ
Enriched GO Terms of Interacting Partners?
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