SEC11A and RAB27B

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SEC11A	RAB27B
Description		SEC11 homolog A, signal peptidase complex subunit	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Late Endosome Golgi Stack Plasma Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane Axon Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Signal Peptide Processing	Platelet Degranulation Melanosome Transport Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Schizophrenia ( 29483656)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		5 interacting genes: ADAM33 BCHE CSNK2B NUPR1 SLC35F6	11 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 SYTL5 UNC13D
Entrez ID		23478	5874
HPRD ID		07503	04846
Ensembl ID		ENSG00000140612	ENSG00000041353
Uniprot IDs		A0A024RC78 H0YKT4 P67812	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?
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