GRIP1 and GRIK2

Data Source:
BioGRID (pull down)

		GRIP1	GRIK2
Description		glutamate receptor interacting protein 1	glutamate ionotropic receptor kainate type subunit 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Dendrite Cytoplasmic Vesicle Neuron Projection Perikaryon Membrane Raft Postsynaptic Membrane Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Beta-catenin Binding Protein C-terminus Binding Signaling Receptor Complex Adaptor Activity Glucocorticoid Receptor Binding	Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Dendrite Development Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Neuron Projection Arborization	Behavioral Fear Response Cellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception
Pathways		Trafficking of GluR2-containing AMPA receptors	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Weight ( 28552196)
Interacting Genes		42 interacting genes: AGAP2 AR CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH	18 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		23426	2898
HPRD ID		19086	00692
Ensembl ID		ENSG00000155974	ENSG00000164418
Uniprot IDs		Q9Y3R0	A8K0H7 Q13002 Q8IY40
PDB IDs		2JIL	3QXM 5CMM
Enriched GO Terms of Interacting Partners?
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