FLT1 and YES1

Data Source:
HPRD (in vivo)

		FLT1	YES1
Description		fms related receptor tyrosine kinase 1	YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Receptor Complex	Golgi Apparatus Microtubule Organizing Center Cytosol Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Placental Growth Factor-activated Receptor Activity	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Angiogenesis Hematopoietic Progenitor Cell Differentiation Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling CD28 co-stimulation CTLA4 inhibitory signaling EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin ABT-869 IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Fostamatinib Selpercatinib	Dasatinib Fostamatinib
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)	Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 30224653 29403010 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GAS8 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE PXN RASA1 RPL10 SH3GLB2 SKAP2 SLC9A3R1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B
Entrez ID		2321	7525
HPRD ID		01297	01285
Ensembl ID		ENSG00000102755	ENSG00000176105
Uniprot IDs		L7RSL3 P17948	P07947
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89	2HDA
Enriched GO Terms of Interacting Partners?
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