FLNC and PHLDB2

Data Source:
HPRD (in vitro, in vivo)

		FLNC	PHLDB2
Description		filamin C	pleckstrin homology like domain family B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Cytosol Plasma Membrane Focal Adhesion Cell Leading Edge Intermediate Filament Cytoskeleton Basal Cortex
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding	Protein Binding Cadherin Binding
	Biological Process	Cell Junction Assembly Muscle Fiber Development	Microtubule Cytoskeleton Organization Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Atrial fibrillation ( 30061737 29892015) Cognitive performance ( 20125193) Crohn's disease-related phenotypes ( 25557950) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 30046033 32439900)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	5 interacting genes: CLK1 FLNC USP7 YWHAG YWHAQ
Entrez ID		2318	90102
HPRD ID		00018	06611
Ensembl ID		ENSG00000128591	ENSG00000144824
Uniprot IDs		Q14315 Q59H94	Q86SQ0
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX
Enriched GO Terms of Interacting Partners?
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