FLNC and MYBPC2

Data Source:
BioGRID (two hybrid)

		FLNC	MYBPC2
Description		filamin C	myosin binding protein C2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Cytosol Myosin Filament
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding	Actin Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Cell Junction Assembly Muscle Fiber Development	Cell Adhesion Muscle Filament Sliding
Pathways		Cell-extracellular matrix interactions	Striated Muscle Contraction
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)	Primary biliary cholangitis ( 26394269)
Interacting Genes		35 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 CDC42 ENO1 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYBPC2 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA REPS1 RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3
Entrez ID		2318	4606
HPRD ID		00018	01184
Ensembl ID		ENSG00000128591	ENSG00000086967
Uniprot IDs		Q14315 Q59H94	A0A140VJQ0 Q14324
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX	2E7C 2EDK 2EDN
Enriched GO Terms of Interacting Partners?
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