SCMH1 and MAML3

Data Source:
BioGRID (two hybrid)

		SCMH1	MAML3
Description		Scm polycomb group protein homolog 1	mastermind like transcriptional coactivator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromocenter	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Transcription Coactivator Activity
	Biological Process	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Mercaptoethanol
Diseases
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435)	Adult body size ( 32376654) Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Malaria ( 31844061) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Social science traits (pleiotropy) (HIPO component 1) ( 30289880)
Interacting Genes		19 interacting genes: EWSR1 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M SFMBT1 SFMBT2 TMEM11 TOB1 UBQLN1 UBQLN4	12 interacting genes: NFX1 NID2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H VPS26C ZBTB1 ZZZ3
Entrez ID		22955	55534
HPRD ID		11540	10066
Ensembl ID		ENSG00000010803	ENSG00000196782
Uniprot IDs		B3KMZ7 Q96GD3	Q96JK9 Q9NPV6
PDB IDs		2P0K
Enriched GO Terms of Interacting Partners?
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